Inhibition of Pseudomonas aeruginosa Biofilm Formation with Surface Modified Polymeric Nanoparticles

被引：29

作者：

Flockton, Tyler R. ^{[1
]}

Schnorbus, Logan ^{[1
]}

Araujo, Agustin ^{[1
]}

Adams, Jill ^{[1
]}

Hammel, Maryjane ^{[1
]}

Perez, Lark J. ^{[1
]}

机构：

[1] Rowan Univ, Dept Chem & Biochem, 201 Mull Hill Rd, Glassboro, NJ 08028 USA

来源：

PATHOGENS | 2019年 / 8卷 / 02期

基金：

美国国家科学基金会;

关键词：

biofilm; inhibition; antivirulence; lectin; Pseudomonas aeruginosa; nanoparticle; CYSTIC-FIBROSIS; VIRULENCE; LECTINS; ANTIBIOTICS; RESISTANCE; INFECTION; GLYCOMIMETICS; SYSTEMS; IMPACT; LECB;

D O I：

10.3390/pathogens8020055

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The gram-negative bacterial pathogen Pseudomonas aeruginosa represents a prominent clinical concern. Due to the observed high levels of antibiotic resistance, copious biofilm formation, and wide array of virulence factors produced by these bacteria, new treatment technologies are required. Here, we present the development of a series of P. aeruginosa LecA-targeted polymeric nanoparticles and demonstrate the anti-adhesion and biofilm inhibitory properties of these constructs.

引用

页数：13

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