Inhibition of Pseudomonas aeruginosa Biofilm Formation with Surface Modified Polymeric Nanoparticles

被引：28
作者：
Flockton, Tyler R. [1 ]
Schnorbus, Logan [1 ]
Araujo, Agustin [1 ]
Adams, Jill [1 ]
Hammel, Maryjane [1 ]
Perez, Lark J. [1 ]
机构：
[1] Rowan Univ, Dept Chem & Biochem, 201 Mull Hill Rd, Glassboro, NJ 08028 USA
来源：
PATHOGENS | 2019年 / 8卷 / 02期
基金：
美国国家科学基金会;
关键词：
biofilm; inhibition; antivirulence; lectin; Pseudomonas aeruginosa; nanoparticle; CYSTIC-FIBROSIS; VIRULENCE; LECTINS; ANTIBIOTICS; RESISTANCE; INFECTION; GLYCOMIMETICS; SYSTEMS; IMPACT; LECB;
D O I：
10.3390/pathogens8020055
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The gram-negative bacterial pathogen Pseudomonas aeruginosa represents a prominent clinical concern. Due to the observed high levels of antibiotic resistance, copious biofilm formation, and wide array of virulence factors produced by these bacteria, new treatment technologies are required. Here, we present the development of a series of P. aeruginosa LecA-targeted polymeric nanoparticles and demonstrate the anti-adhesion and biofilm inhibitory properties of these constructs.
引用
收藏
页数：13
相关论文
共 44 条
  • [1] CYTOTOXICITY OF PSEUDOMONAS-AERUGINOSA INTERNAL LECTIN PA-I TO RESPIRATORY EPITHELIAL-CELLS IN PRIMARY CULTURE
    BAJOLETLAUDINAT, O
    GIRODDEBENTZMANN, S
    TOURNIER, JM
    MADOULET, C
    PLOTKOWSKI, MC
    CHIPPAUX, C
    PUCHELLE, E
    [J]. INFECTION AND IMMUNITY, 1994, 62 (10) : 4481 - 4487
  • [2] Nanoparticles for Imaging, Sensing, and Therapeutic Intervention
    Bogart, Lara K.
    Pourroy, Genevieve
    Murphy, Catherine J.
    Puntes, Victor
    Pellegrino, Teresa
    Rosenblum, Daniel
    Peer, Dan
    Levy, Raphael
    [J]. ACS NANO, 2014, 8 (04) : 3107 - 3122
  • [3] Antibacterial drug discovery in the resistance era
    Brown, Eric D.
    Wright, Gerard D.
    [J]. NATURE, 2016, 529 (7586) : 336 - 343
  • [4] Development of a novel series of non-natural triaryl agonists and antagonists of the Pseudomonas aeruginosa LasR quorum sensing receptor
    Capilato, Joseph N.
    Philippi, Shane V.
    Reardon, Thomas
    McConnell, Ashleigh
    Oliver, Dylan C.
    Warren, Amy
    Adams, Jill S.
    Wu, Chun
    Perez, Lark J.
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2017, 25 (01) : 153 - 165
  • [5] New methodologies in the construction of dendritic materials
    Carlmark, Anna
    Hawker, Craig J.
    Hult, Anders
    Malkoch, Michael
    [J]. CHEMICAL SOCIETY REVIEWS, 2009, 38 (02) : 352 - 362
  • [6] Glycomimetics versus Multivalent Glycoconjugates for the Design of High Affinity Lectin Ligands
    Cecioni, Samy
    Imberty, Anne
    Vidal, Sebastien
    [J]. CHEMICAL REVIEWS, 2015, 115 (01) : 525 - 561
  • [7] Centers for Disease Control and Prevention (CDC), 2013, Antibiotic Resistance Threats in the United States
  • [8] Role of LecA and LecB Lectins in Pseudomonas aeruginosa-Induced Lung Injury and Effect of Carbohydrate Ligands
    Chemani, Chanez
    Imberty, Anne
    de Bentzmann, Sophie
    Pierre, Maud
    Wimmerova, Michaela
    Guery, Benoit P.
    Faure, Karine
    [J]. INFECTION AND IMMUNITY, 2009, 77 (05) : 2065 - 2075
  • [9] In vitro and in vivo model systems to study microbial biofilm formation
    Coenye, Tom
    Nelis, Hans J.
    [J]. JOURNAL OF MICROBIOLOGICAL METHODS, 2010, 83 (02) : 89 - 105
  • [10] Optimization of cell receptor-specific targeting through multivalent surface decoration of polymeric nanocarriers
    D'Addio, Suzanne M.
    Baldassano, Steven
    Shi, Lei
    Cheung, Lila
    Adamson, Douglas H.
    Bruzek, Matthew
    Anthony, John E.
    Laskin, Debra L.
    Sinko, Patrick J.
    Prud'homme, Robert K.
    [J]. JOURNAL OF CONTROLLED RELEASE, 2013, 168 (01) : 41 - 49
12345