Prognostic value of total triiodothyronine and free thyroxine levels for the heart failure in patients with acute myocardial infarction

Background/Aims: Although a low triiodothyronine (T-3) state is closely associated with heart failure (HF), it is uncertain whether total T-3 levels on admission is correlated with the clinical outcomes of acute myocardial infarction (AMI). The aim of this study is to investigate the prognostic value of total 13 levels for major adverse cardiovascular and cerebrovascular events (MACCEs) in patients with AMI undergone percutaneous coronary intervention (PCI). Methods: A total of 765 PCI-treated AMI patients (65.4 +/- 12.6 years old, 215 women) between January 2012 and July 2014 were included and 1-year MACCEs were analyzed. We assessed the correlation of total 13 and free thyroxine (fT(4)) with prevalence of 1-year MACCE s and the predictive values of total T-3, fT(4), and the ratio of total T-3 to fT(4) (T-3/fT(4)), especially for HF requiring re-hospitalization. Results: Thirty patients (3.9%) were re-hospitalized within 12 months to control HF symptoms. Total T3 levels were lower in the HF group than in the non-HF group (84.32 +/- 21.04 ng/dL vs. 101.20 +/- 20.30 ng/dL, p < 0.00l). Receiver operating characteristic curve analysis showed the cut-offs of total T3 levels 85 ng/dL) and 60) for HF (area under curve [AUG] = 0.734, p < 0.001, AUG = 0.774,) < 0.001, respectively). In multivariate analysis, lower T-3/fT(4) was an independent predictor for 1-year HF in PCI-treated AMI patients (odds ratio, 1.035; 95% confidential interval, 1.007 to 1.064; p = 0.015). Conclusions: Lower levels of total T-3 were well correlated with 1-year HF in PCI-treated AMI patients. The T-3/fT(4) levels can be an additional marker to predict HF.