Expression of α-synuclein, the precursor of non-amyloid β component of Alzheimer's disease amyloid, in human cerebral blood vessels

被引：56
|
作者：
Tamo, W
Imaizumi, T [1 ]
Tanji, K
Yoshida, H
Mori, F
Yoshimoto, M
Takahashi, H
Fukuda, I
Wakabayashi, K
Satoh, K
机构：
[1] Hirosaki Univ, Sch Med, Inst Brain Sci, Dept Vasc Biol, Hirosaki, Aomori 0368562, Japan
[2] Hirosaki Univ, Sch Med, Inst Brain Sci, Dept Mol Biol, Hirosaki, Aomori 0368562, Japan
[3] Taisho Pharmaceut Co Ltd, Med Res Labs, Mol Biol Lab, Omiya, Saitama 3308530, Japan
[4] Niigata Univ, Brain Res Inst, Dept Pathol, Niigata 9518585, Japan
[5] Hirosaki Univ, Sch Med, Dept Surg 1, Hirosaki, Aomori 0368562, Japan
来源：
NEUROSCIENCE LETTERS | 2002年 / 326卷 / 01期
基金：
日本学术振兴会;
关键词：
alpha-synuclein; endothelial cells; smooth muscle cells; amyloid beta; non-amyloid beta component; precursor of non-amyloid beta component; Parkinson's disease; Alzheimer's disease;
D O I：
10.1016/S0304-3940(02)00297-5
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The non-amyloid beta component of Alzheimer's disease amyloid (NAC) is detected in cerebral amyloid angiopathy; and the precursor of NAC is now known to be identical to alpha-synuclein (alpha-S), a major component of Lewy bodies in Parkinson's disease. We studied if cerebral vascular cells express alpha-S. Immunohistochemical studies of human cerebral tissues from control and cerebral amyloid angiopathy patients revealed the expression of alpha-S in vascular endothelial and smooth muscle cells. Then we studied the expression of alpha-S in vitro using cultures of vascular cells. Cultures of human umbilical vein endothelial cells and umbilical artery smooth muscle cells were found to constitutively express alpha-S messenger RNA and protein. alpha-S is normally expressed in vascular cells and may play some physiological role in the vascular wall. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：5 / 8
页数：4
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