11C-PiB PET Imaging of Encephalopathy Associated with Cerebral Amyloid Angiopathy

被引：13

作者：

Sengoku, Renpei ^{[1
,2
]}

Matsushima, Satoshi ^{[3
]}

Murakami, Yoshitake ^{[4
]}

Fukuda, Takahiro ^{[5
]}

Tokumaru, Aya M. ^{[6
]}

Hashimoto, Masaya ^{[1
]}

Suzuki, Masahiko ^{[1
]}

Ishiwata, Kiichi ^{[7
]}

Ishii, Kenji ^{[7
]}

Mochio, Soichiro ^{[8
]}

机构：

[1] Jikei Univ Sch Med, Dept Neurol, Minato, Tokyo, Japan

[2] Tokyo Metropolitan Geriatr Hosp, Dept Neurol, Tokyo, Japan

[3] Jikei Univ Sch Med, Dept Radiol, Minato, Tokyo, Japan

[4] Saiseikai Kurihashi Hosp, Dept Neurol, Saitama, Japan

[5] Jikei Univ Sch Med, Dept Neuropathol, Minato, Tokyo, Japan

[6] Tokyo Metropolitan Med Ctr Gerontol, Dept Diagnost Radiol, Tokyo, Japan

[7] Tokyo Metropolitan Inst Gerontol, Positron Med Ctr, Tokyo, Japan

[8] Jikei Univ Sch Nursing, Minato, Tokyo, Japan

来源：

INTERNAL MEDICINE | 2014年 / 53卷 / 17期

关键词：

cerebral amyloid angiopathy; vasogenic edema; PET; sensory aphasia; hemodialysis; LEUKOENCEPHALOPATHY; INFLAMMATION;

D O I：

10.2169/internalmedicine.53.1731

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We herein report that the clinical, laboratory, and radiographic features and positron emission tomography (PET) imaging may provide valuable clues to the pathogenesis of cerebral amyloid angiopathy (CAA)-associated encephalopathy, which currently remains unclear. We herein describe two cases of encephalopathy with CAA, with an emphasis on PET imaging with C-11-Pittsburgh compound B (C-11-PiB) and F-18-fluorodeoxyglucose (F-18-FDG). One case of Alzheimer's disease for which a brain biopsy was performed showed CAA-related inflammation. Another case that had developed sudden sensory aphasia presented with posterior reversible encephalopathy syndrome-like vasogenic edema in the left temporal region with C-11-PiB uptake and microhemorrhages. C-11-PiB and F-18-FDG PET are useful for detecting CAA-associated encephalopathy, including atypical CAA cases.

引用

页码：1997 / 2000

页数：4

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