Updates on immunotherapy for colorectal cancer

被引：126

作者：

Kalyan, Aparna ^{[1
,2
]}

Kircher, Sheetal ^{[2
]}

Shah, Hiral ^{[1
,2
]}

Mulcahy, Mary ^{[2
]}

Benson, Al ^{[2
]}

机构：

[1] Feinberg Sch Med, Div Hematol & Oncol, Dev Therapeut Program, Chicago, IL USA

[2] Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA

来源：

JOURNAL OF GASTROINTESTINAL ONCOLOGY | 2018年 / 9卷 / 01期

关键词：

Colorectal cancer (CRC); immunotherapy; microsatellite instability (MSI); vaccine therapy; ACTIVE SPECIFIC IMMUNOTHERAPY; PHASE-I; COLON-CANCER; CARCINOEMBRYONIC ANTIGEN; LIVER METASTASES; DENDRITIC CELLS; TUMOR-CELLS; PEPTIDE; VACCINE; VIRUS;

D O I：

10.21037/jgo.2018.01.17

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Despite significant advances in standard of care therapies, the 5-year survival rate for metastatic colorectal cancer (CRC) remains around 12%. Immunotherapy has not provided the stellar advances in colorectal cancer that has been seen in other malignancies. Immunotherapy appears to play a pivotal role in microsatellite unstable CRC tumors where the response rates are profound. These results have led to FDA approval of pembrolizumab for MSI-H CRC tumors. Additional research into several new immune agents including IDO inhibitors, vaccine therapy and combinatorial agents are being evaluated for CRC. This review will provide an overview of the approaches currently being investigated.

引用

页码：160 / 169

页数：10

共 78 条

[21] Over-Expression of TRESK K+ Channels Reduces the Excitability of Trigeminal Ganglion Nociceptors [J].

Guo, Zhaohua ;

Cao, Yu-Qing .

PLOS ONE, 2014, 9 (01)

[22] A phase II study of five peptides combination with oxaliplatin-based chemotherapy as a first-line therapy for advanced colorectal cancer (FXV study) [J].

Hazama, Shoichi ;

Nakamura, Yusuke ;

Tanaka, Hiroaki ;

Hirakawa, Kosei ;

Tahara, Ko ;

Shimizu, Ryoichi ;

Ozasa, Hiroaki ;

Etoh, Ryuichi ;

Sugiura, Fumiaki ;

Okuno, Kiyotaka ;

Furuya, Takumi ;

Nishimura, Taku ;

Sakata, Koichiro ;

Yoshimatsu, Kazuhiko ;

Takenouchi, Hiroko ;

Tsunedomi, Ryouichi ;

Inoue, Yuka ;

Kanekiyo, Shinsuke ;

Shindo, Yoshitaro ;

Suzuki, Nobuaki ;

Yoshino, Shigefumi ;

Shinozaki, Hirokazu ;

Kamiya, Akira ;

Furukawa, Hiroyuki ;

Yamanaka, Takeharu ;

Fujita, Tomonobu ;

Kawakami, Yutaka ;

Oka, Masaaki .

JOURNAL OF TRANSLATIONAL MEDICINE, 2014, 12

[23] Diagnostic approach and management of Lynch syndrome (Hereditary Nonpolyposis Colorectal Carcinoma):: A guide for clinicians [J].

Hendriks, Yvonne M. C. ;

de Jong, Andrea E. ;

Morreau, Hans ;

Tops, Carli M. J. ;

Vasen, Hans F. ;

Wijnen, Juul Th. ;

Breuning, Martijn H. ;

Brocker-Vriends, Annette H. J. T. .

CA-A CANCER JOURNAL FOR CLINICIANS, 2006, 56 (04) :213-225

[24] Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma [J].

Herman, JG ;

Umar, A ;

Polyak, K ;

Graff, JR ;

Ahuja, N ;

Issa, JPJ ;

Markowitz, S ;

Willson, JKV ;

Hamilton, SR ;

Kinzler, KW ;

Kane, MF ;

Kolodner, RD ;

Vogelstein, B ;

Kunkel, TA ;

Baylin, SB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (12) :6870-6875

[25] Enzyme-Linked Immunosorbent Spot Assay for the Detection of Wilms' Tumor 1-Specific T Cells Induced by Dendritic Cell Vaccination [J].

Higuchi, Yumiko ;

Koya, Terutsugu ;

Yuzawa, Miki ;

Yamaoka, Naoko ;

Mizuno, Yumiko ;

Yoshizawa, Kiyoshi ;

Hirabayashi, Koichi ;

Kobayashi, Takashi ;

Sano, Kenji ;

Shimodaira, Shigetaka .

BIOMEDICINES, 2015, 3 (04) :304-315

[26] Improved Survival with Ipilimumab in Patients with Metastatic Melanoma [J].

Hodi, F. Stephen ;

O'Day, Steven J. ;

McDermott, David F. ;

Weber, Robert W. ;

Sosman, Jeffrey A. ;

Haanen, John B. ;

Gonzalez, Rene ;

Robert, Caroline ;

Schadendorf, Dirk ;

Hassel, Jessica C. ;

Akerley, Wallace ;

van den Eertwegh, Alfons J. M. ;

Lutzky, Jose ;

Lorigan, Paul ;

Vaubel, Julia M. ;

Linette, Gerald P. ;

Hogg, David ;

Ottensmeier, Christian H. ;

Lebbe, Celeste ;

Peschel, Christian ;

Quirt, Ian ;

Clark, Joseph I. ;

Wolchok, Jedd D. ;

Weber, Jeffrey S. ;

Tian, Jason ;

Yellin, Michael J. ;

Nichol, Geoffrey M. ;

Hoos, Axel ;

Urba, Walter J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (08) :711-723

[27]

HOSTER HA, 1949, CANCER RES, V9, P473

[28] Therapeutic effect of CD137 immunomodulation in lymphoma and its enhancement by Treg depletion [J].

Houot, Roch ;

Goldstein, Matthew J. ;

Kohrt, Holbrook E. ;

Myklebust, June H. ;

Alizadeh, Ash A. ;

Lin, Jack T. ;

Irish, Jonathan M. ;

Torchia, James A. ;

Kolstad, Arne ;

Chen, Lieping ;

Levy, Ronald .

BLOOD, 2009, 114 (16) :3431-3438

[29] The feasibility of Cep55/c10orf3 derived peptide vaccine therapy for colorectal carcinoma [J].

Inoda, Satoko ;

Morita, Rena ;

Hirohashi, Yoshihiko ;

Torigoe, Toshihiko ;

Asanuma, Hiroko ;

Nakazawa, Emiri ;

Nakatsugawa, Munehide ;

Tamura, Yasuaki ;

Kamiguchi, Kenjiro ;

Tsuruma, Tetsuhiro ;

Terui, Takeshi ;

Ishitani, Kunihiko ;

Hashino, Satoshi ;

Wang, Qiang ;

Greene, Mark I. ;

Hasegawa, Tadashi ;

Hirata, Koichi ;

Asaka, Masahiro ;

Sato, Noriyuki .

EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2011, 90 (01) :55-60

[30] Immunotherapy of solid cancer using dendritic cells pulsed with the HLA-A24-restricted peptide of carcinoembryonic antigen [J].

Itoh, T ;

Ueda, Y ;

Kawashima, I ;

Nukaya, I ;

Fujiwara, H ;

Fuji, N ;

Yamashita, T ;

Yoshimura, T ;

Okugawa, K ;

Iwasaki, T ;

Ideno, N ;

Takesako, K ;

Mitsuhashi, M ;

Orita, K ;

Yamagishi, H .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2002, 51 (02) :99-106

← 1 2 3 4 5 6 7 8 →