Pancreatic carcinoma with brain metastases: case report and literature review

被引：15
作者：
El Kamar, FG
Jindal, K
Grossbard, ML
Mizrachi, HH
Kozuch, PS
机构：
[1] Columbia Univ Coll Phys & Surg, St Lukes Roosevelt Hosp Ctr, New York, NY 10019 USA
[2] Beth Israel Deaconess Med Ctr, New York, NY 10003 USA
[3] White Plains Hosp, Dept Pathol & Lab Med, White Plains, NY 10601 USA
来源：
DIGESTIVE AND LIVER DISEASE | 2004年 / 36卷 / 05期
关键词：
brain metastases; chemotherapy; gemcitabine; pancreatic cancer;
D O I：
10.1016/j.dld.2003.10.019
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The case of a patient developing multiple brain metastases from carcinoma of the exocrine pancreas has been described. A 56-year-old man with stage IV pancreatic cancer attained a clinical and radiographic response while receiving the G-FLIP chemotherapy regimen (biweekly gemcitabine. irinotecan. 5-fluorouracil, leucovorin and cisplatin). After 4 months of therapy, he developed gait imbalance and weakness in the right hand. An MRI of the brain showed multiple 1-2 mm enhancing nodules in the cerebral hemispheres and pons. A Subsequent biopsy confirmed that these were pancreatic carcinoma metastases. The patient experienced a rapid deterioration in his neurological status and died 3 days after brain biopsy. Previously reported cases of brain metastases from pancreatic cancer are reviewed. (C) 2004 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：355 / 360
页数：6
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