Epothilones and related structures - a new class of microtubule inhibitors with potent in vivo antitumor activity

被引：197

作者：

Altmann, KH ^{[1
]}

Wartmann, M ^{[1
]}

O'Reilly, T ^{[1
]}

机构：

[1] Novartis Pharma AG, TA Oncol Res, CH-4002 Basel, Switzerland

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2000年 / 1470卷 / 03期

关键词：

D O I：

10.1016/S0304-419X(00)00009-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[No abstract available]

引用

页码：M79 / M91

页数：13

共 61 条

[1]

ALTMANN KH, IN VIVO ACTIVITY PRO

[2]

[Anonymous], [No title captured], Patent No. [DE 4138042, 4138042]

[3] Stereoselective syntheses and evaluation of compounds in the 8-desmethylepothilone A series: Some surprising observations regarding their chemical and biological properties [J].

Balog, A ;

Bertinato, P ;

Su, DS ;

Meng, DF ;

Sorensen, E ;

Danishefsky, SJ ;

Zheng, YH ;

Chou, TC ;

He, LE ;

Horwitz, SB .

TETRAHEDRON LETTERS, 1997, 38 (26) :4529-4532

[4]

Blagosklonny MV, 1997, CANCER RES, V57, P130

[5]

Blagosklonny MV, 1996, CANCER RES, V56, P1851

[6]

BOLLAG DM, 1995, CANCER RES, V55, P2325

[7] Desoxyepothilone B is curative against human tumor xenografts that are refractory to paclitaxel [J].

Chou, TC ;

Zhang, XG ;

Harris, CR ;

Kuduk, SD ;

Balog, A ;

Savin, KA ;

Bertino, JR ;

Danishefsky, SJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (26) :15798-15802

[8] Desoxyepothilone B:: An efficacious microtubule-targeted antitumor agent with a promising in vivo profile relative to epothilone B [J].

Chou, TC ;

Zhang, XG ;

Balog, A ;

Su, DS ;

Meng, DF ;

Savin, K ;

Bertino, JR ;

Danishefsky, SJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (16) :9642-9647

[9] Epothilons A and B: Antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria) - Production, physico-chemical and biological properties [J].

Gerth, K ;

Bedorf, N ;

Hofle, G ;

Irschik, H ;

Reichenbach, H .

JOURNAL OF ANTIBIOTICS, 1996, 49 (06) :560-563

[10]

Giannakakou P., 1999, Proceedings of the American Association for Cancer Research Annual Meeting, V40, P284

← 1 2 3 4 5 6 7 →