Dietary docosahexaenoic acid can alter the surface expression of CD4 and CD8 on T cells in peripheral blood

被引：12

作者：

Sasaki, T

Kanke, Y

Nagahashi, M

Toyokawa, M

Matsuda, M

Shimizu, J

Misawa, Y

Takita, T

机构：

[1] Tokyo Univ Agr, Fac Appl Biol Sci, Dept Nutr Sci, Lab Food Component Chem,Setagaya Ku, Tokyo 1568502, Japan

[2] Tokyo Univ Agr, Grad Sch Agr, Dept Bioregulat Studies, Setagaya Ku, Tokyo 1568502, Japan

[3] Tokyo Univ Agr, Grad Sch Agr, Dept Food Nutr, Setagaya Ku, Tokyo 1568502, Japan

[4] Harima Chem Inc, Tsukuba, Ibaraki 3002635, Japan

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2000年 / 48卷 / 04期

关键词：

docosahexaenoic acid; CD4; CD8; T cells; surface expression; peripheral blood;

D O I：

10.1021/jf990358i

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

The effect of dietary docosahexaenoic acid (DHA) on T cell states in peripheral blood was investigated. Weanling male C57B1/6N mice were kept on one of three 10% fat diets containing various amounts of DHA and linoleic acid for 4 weeks. Changing the concentration of dietary DHA did not alter the proportion of T cells expressing CD4 or CD8. However, increasing the concentration of dietary DHA lowered the expression of CD4 and CD8 on the cell surface. The decreased expression of these surface molecules involved in T cell proliferation has serious implications in the role of DHA as an immunosuppressant.

引用

页码：1047 / 1049

页数：3

共 50 条

[21] Extrathymic CD4/CD8 double positive T cells
Zuckermann, FA
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 1999, 72 (1-2) : 55 - 66
[22] Differential survival of naive CD4 and CD8 T cells
Ferreira, C
Barthlott, T
Garcia, S
Zamoyska, R
Stockinger, B
JOURNAL OF IMMUNOLOGY, 2000, 165 (07): : 3689 - 3694
[23] CD4 and CD8 regulatory T cells in multiple sclerosis
Karandikar, Nitin J.
JOURNAL OF NEUROIMMUNOLOGY, 2008, 203 (02) : 260 - 260
[24] Blind T-cell homeostasis and the CD4/CD8 ratio in the thymus and peripheral blood
Mehr, R
Perelson, AS
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY, 1997, 14 (05): : 387 - 398
[25] Peripheral blood CD4(+)CD8(+) lymphocytes in cynomolgus monkeys are of resting memory T lineage
Akari, H
Terao, K
Murayama, Y
Nam, KH
Yoshikawa, Y
INTERNATIONAL IMMUNOLOGY, 1997, 9 (04) : 591 - 597
[26] CD4 and CD8 T cells differ in their proliferative responses
Alice Lorenzi
Arthritis Research & Therapy, 4 (1)
[27] Direct CD8:CD4 T cell interactions improve memory recall of CD8 T cells
Romagnoli, Pablo Alberto
Premenko-Lanier, Mary F.
Loria, Gilbert David
Altman, John David
JOURNAL OF IMMUNOLOGY, 2009, 182
[28] Unravelling the biology of double-positive CD4/CD8αβ T cells in peripheral tissues
Kong, Wei Yang
Soderholm, Amelia
de Oca, Marcela Montes
Chew, Hui Yi
Brooks, Andrew
Cruz, Jazmina
Wells, James
JOURNAL OF IMMUNOLOGY, 2024, 212 (01):
[29] EXPRESSION OF CD4 AND CD8 ON HEMATOPOIETIC PROGENITORS
NIMGAONKAR, M
LANCIA, J
NEUDORF, S
BALL, ED
EXPERIMENTAL HEMATOLOGY, 1994, 22 (08) : 787 - 787
[30] Quantitation of microchimeric CD4 and CD8 positive T cells in peripheral blood from women with systemic sclerosis.
Artlett, CM
Cox, LA
Fortunato, RA
Hummers, L
Jimenez, SA
Smith, JB
ARTHRITIS AND RHEUMATISM, 1999, 42 (09): : S207 - S207

← 1 2 3 4 5 →