Dietary docosahexaenoic acid can alter the surface expression of CD4 and CD8 on T cells in peripheral blood

被引：12
|
作者：
Sasaki, T
Kanke, Y
Nagahashi, M
Toyokawa, M
Matsuda, M
Shimizu, J
Misawa, Y
Takita, T
机构：
[1] Tokyo Univ Agr, Fac Appl Biol Sci, Dept Nutr Sci, Lab Food Component Chem,Setagaya Ku, Tokyo 1568502, Japan
[2] Tokyo Univ Agr, Grad Sch Agr, Dept Bioregulat Studies, Setagaya Ku, Tokyo 1568502, Japan
[3] Tokyo Univ Agr, Grad Sch Agr, Dept Food Nutr, Setagaya Ku, Tokyo 1568502, Japan
[4] Harima Chem Inc, Tsukuba, Ibaraki 3002635, Japan
来源：
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2000年 / 48卷 / 04期
关键词：
docosahexaenoic acid; CD4; CD8; T cells; surface expression; peripheral blood;
D O I：
10.1021/jf990358i
中图分类号：
S [农业科学];
学科分类号：
09 ;
摘要：
The effect of dietary docosahexaenoic acid (DHA) on T cell states in peripheral blood was investigated. Weanling male C57B1/6N mice were kept on one of three 10% fat diets containing various amounts of DHA and linoleic acid for 4 weeks. Changing the concentration of dietary DHA did not alter the proportion of T cells expressing CD4 or CD8. However, increasing the concentration of dietary DHA lowered the expression of CD4 and CD8 on the cell surface. The decreased expression of these surface molecules involved in T cell proliferation has serious implications in the role of DHA as an immunosuppressant.
引用
收藏
页码：1047 / 1049
页数：3
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