Sex disparities in cystic fibrosis: review on the effect of female sex hormones on lung pathophysiology and outcomes

被引：31

作者：

Lam, Grace Y. ^{[1
,2
]}

Goodwin, Jodi ^{[2
]}

Wilcox, Pearce G. ^{[2
]}

Quon, Bradley S. ^{[1
,2
]}

机构：

[1] Univ British Columbia, Ctr Heart Lung Innovat, St Pauls Hosp, 1081 Burrard St, Vancouver, BC V6Z 1Y6, Canada

[2] St Pauls Hosp, Adult Cyst Fibrosis Program, Vancouver, BC, Canada

来源：

ERJ OPEN RESEARCH | 2021年 / 7卷 / 01期

关键词：

GENDER-DIFFERENCES; REGULATOR EXPRESSION; ESTROGEN; WOMEN; INFLAMMATION; HEALTH; YOUTH; ASSOCIATIONS; PHYSIOLOGY; MORTALITY;

D O I：

10.1183/23120541.00475-2020

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Sex differences in morbidity and mortality have been reported in the cystic fibrosis (CF) population worldwide. However, it is unclear why CF women have worse clinical outcomes than men. In this review, we focus on the influence of female sex hormones on CF pulmonary outcomes and summarise data from in vitro and in vivo experiments on how oestrogen and progesterone might modify mucociliary clearance, immunity and infection in the CF airways. The potential for novel sex hormone-related therapeutic interventions is also discussed.

引用

页码：1 / 11

页数：11

共 75 条

[1] Females with cystic fibrosis have a larger decrease in sweat chloride in response to lumacaf tor/ivacaf tor compared to males [J].

Aalbers, B. L. ;

Hofland, R. W. ;

Bronsveld, I. ;

Groot, K. M. de Winter-de ;

Arets, H. G. M. ;

Kiviet, A. C. de ;

Ven, M. M. M. van Oirschot-van de ;

Kruijswijk, M. A. ;

Schotman, S. ;

Michel, S. ;

Ent, C. K. van der ;

Heijerman, H. G. M. .

JOURNAL OF CYSTIC FIBROSIS, 2021, 20 (01) :E7-E11

[2] 17β-Estradiol Dysregulates Innate Immune Responses to Pseudomonas aeruginosa Respiratory Infection and Is Modulated by Estrogen Receptor Antagonism [J].

Abid, Shadaan ;

Xie, ShangKui ;

Bose, Moumita ;

Shaul, Philip W. ;

Terada, Lance S. ;

Brody, Steven L. ;

Thomas, Philip J. ;

Katzenellenbogen, John A. ;

Kim, Sung Hoon ;

Greenberg, David E. ;

Jain, Raksha .

INFECTION AND IMMUNITY, 2017, 85 (10)

[3] Estrogen-induced abnormally high cystic fibrosis transmembrane conductance regulator expression results in ovarian hyperstimulation syndrome [J].

Ajonuma, LC ;

Tsang, LL ;

Zhang, GH ;

Wong, CHY ;

Lau, MC ;

Ho, LS ;

Rowlands, DK ;

Zhou, CX ;

Ng, CP ;

Chen, J ;

Xu, PH ;

Zhu, JX ;

Chung, YW ;

Chan, HC .

MOLECULAR ENDOCRINOLOGY, 2005, 19 (12) :3038-3044

[4]

[Anonymous], 2019, AM J RESP CRIT CARE

[5] Gender, Estrogen, and Obliterative Lesions in the Lung [J].

Assaggaf, Hamza ;

Felty, Quentin .

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, 2017, 2017

[6] Prospective study of postmenopausal hormone use and newly diagnosed asthma and chronic obstructive pulmonary disease [J].

Barr, RG ;

Wentowski, CC ;

Grodstein, F ;

Somers, SC ;

Stampfer, MJ ;

Schwartz, J ;

Speizer, FE ;

Camargo, CA .

ARCHIVES OF INTERNAL MEDICINE, 2004, 164 (04) :379-386

[7] The Anti-Inflammatory Effects of Testosterone [J].

Bianchi, Vittorio Emanuele .

JOURNAL OF THE ENDOCRINE SOCIETY, 2019, 3 (01) :91-107

[8] Reference percentiles for FEV1 and BMI in European children and adults with cystic fibrosis [J].

Boelle, Pierre-Yves ;

Viviani, Laura ;

Busson, Pierre-Francois ;

Olesen, Hanne V. ;

Ravilly, Sophie ;

Stern, Martin ;

Assael, Baroukh M. ;

Barreto, Celeste ;

Drevinek, Pavel ;

Thomas, Muriel ;

Krivec, Uros ;

Mei-Zahav, Meir ;

Vibert, Jean-Francois ;

Clement, Annick ;

Mehta, Anil ;

Corvol, Harriet .

ORPHANET JOURNAL OF RARE DISEASES, 2012, 7

[9] Signal Pathway of 17β-Estradiol-Induced MUC5B Expression in Human Airway Epithelial Cells [J].

Choi, Hye Joung ;

Chung, Yoo-Sam ;

Kim, Hyun Jik ;

Moon, Uk Yeol ;

Choi, Yeon Ho ;

Van Seuningen, Isabelle ;

Baek, Seung Joon ;

Yoon, Ho-Geun ;

Yoon, Joo-Heon .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2009, 40 (02) :168-178

[10] Effect of Estrogen on Pseudomonas Mucoidy and Exacerbations in Cystic Fibrosis [J].

Chotirmall, Sanjay H. ;

Smith, Stephen G. ;

Gunaratnam, Cedric ;

Cosgrove, Sonya ;

Dimitrov, Borislav D. ;

O'Neill, Shane J. ;

Harvey, Brian J. ;

Greene, Catherine M. ;

McElvaney, Noel G. .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (21) :1978-1986

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