Evaluation of imidazo[2,1-b]thiazole-based anticancer agents in one decade (2011-2020): Current status and future prospects

被引：40
作者：
Sbenati, Rawan M. [1 ]
Semreen, Mohammad H. [1 ,2 ]
Semreen, Ahlam M. [2 ]
Shehata, Mahmoud K. [2 ]
Alsaghir, Fai M. [2 ]
El-Gamal, Mohammed, I [1 ,2 ,3 ]
机构：
[1] Univ Sharjah, Sharjah Inst Med Res, Sharjah 27272, U Arab Emirates
[2] Univ Sharjah, Coll Pharm, Dept Med Chem, Sharjah 27272, U Arab Emirates
[3] Univ Mansoura, Fac Pharm, Dept Med Chem, Mansoura 35516, Egypt
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2021年 / 29卷
关键词：
Anticancer; Antiproliferative; Imidazo[2,1-b]thiazole; Imidazothiazole; Kinase inhibitor; Tubulin; ANTIPROLIFERATIVE ACTIVITY; BIOLOGICAL EVALUATION; CYTOTOXIC ACTIVITY; DERIVATIVES; DESIGN; INHIBITORS; ANALOGS; SERIES; KINASE;
D O I：
10.1016/j.bmc.2020.115897
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Several reports have highlighted imidazo[2,1-b]thiazole derivatives as potential antiproliferative agents. They act through kinase inhibition, tubulin inhibition, and other molecular mechanisms of action. In the current article, we reviewed the imidazo[2,1-b]thiazole-based compounds that were reported as anticancer agents. Their biological characteristics as well as structure-activity relationship (SAR) have been reviewed and evaluated. Our main focus was on the reports published in the literature from 2011 to 2020.
引用
收藏
页数：12
相关论文
共 33 条
[1]   Broad-spectrum antiproliferative activity of a series of 6-(4-fluorophenyl)-5-(2-substituted pyrimidin-4-yl)imidazo[2,1-b]thiazole derivatives [J].
Abdel-Maksoud, Mohammed S. ;
El-Gamal, Mohammed I. ;
El-Din, Mahmoud M. Gamal ;
Kwak, Seong-Shin ;
Kim, Hyun-Il ;
Oh, Chang-Hyun .
MEDICINAL CHEMISTRY RESEARCH, 2016, 25 (05) :824-833
[2]   Design, synthesis, in vitro antiproliferative evaluation, and kinase inhibitory effects of a new series of imidazo[2,1-b]thiazole derivatives [J].
Abdel-Maksoud, Mohammed S. ;
Kim, Mi-Ryeong ;
El-Gamal, Mohammed I. ;
El-Din, Mahmoud M. Gamal ;
Tae, Jinsung ;
Choi, Hong Seok ;
Lee, Kyung-Tae ;
Yoo, Kyung Ho ;
Oh, Chang-Hyun .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 95 :453-463
[3]   Anticancer profile of newly synthesized BRAF inhibitors possess 5-(pyrimidin-4-yl)imidazo[2,1-b]thiazole scaffold [J].
Abdel-Maksouda, Mohammed S. ;
Ammar, Usama M. ;
Oh, Chang-Hyun .
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 27 (10) :2041-2051
[4]   Synthesis, in vitro anticancer evaluation and in silico studies of novel imidazo[2,1-b]thiazole derivatives bearing pyrazole moieties [J].
Ali, Ahmed R. ;
El-Bendary, Eman R. ;
Ghaly, Mariam A. ;
Shehata, Ihsan A. .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 75 :492-500
[5]   IMIDAZO[2,1-B]THIAZOLES - ANALOGS OF LEVAMISOLE [J].
AMAROUCH, H ;
LOISEAU, PR ;
BACHA, C ;
CAUJOLLE, R ;
PAYARD, M ;
LOISEAU, PM ;
BORIES, C ;
GAYRAL, P .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1987, 22 (05) :463-466
[6]   Structural optimization of imidazothiazole derivatives affords a new promising series as B-Raf V600E inhibitors; synthesis, in vitro assay and in silico screening [J].
Ammar, Usama M. ;
Abdel-Maksoud, Mohammed S. ;
Ali, Eslam M. H. ;
Mersal, Karim, I ;
Yoo, Kyung Ho ;
Oh, Chang-Hyun .
BIOORGANIC CHEMISTRY, 2020, 100
[7]   Imidazothiazole-based potent inhibitors of V600E-B-RAF kinase with promising anti-melanoma activity: biological and computational studies [J].
Anbar, Hanan S. ;
El-Gamal, Mohammed, I ;
Tarazi, Hamadeh ;
Lee, Bong S. ;
Jeon, Hong R. ;
Kwon, Dow ;
Oh, Chang-Hyun .
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2020, 35 (01) :1712-1726
[8]   Substituted 3-(5-Imidazo[2,1-b]thiazolylmethylene)-2-indolinones and Analogues: Synthesis, Cytotoxic Activity, and Study of the Mechanism of Action [J].
Andreani, Aldo ;
Granaiola, Massimiliano ;
Locatelli, Alessandra ;
Morigi, Rita ;
Rambaldi, Mirella ;
Varoli, Lucilla ;
Calonghi, Natalia ;
Cappadone, Concettina ;
Farruggia, Giovanna ;
Stefanelli, Claudio ;
Masotti, Lanfranco ;
Nguyen, Tam L. ;
Hamel, Ernest ;
Shoemaker, Robert H. .
JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (05) :2078-2088
[9]   Imidazo[2,1-b]thiazole guanylhydrazones as RSK2 inhibitors [1] [J].
Andreani, Aldo ;
Granaiola, Massimiliano ;
Leoni, Alberto ;
Locatelli, Alessandra ;
Morigi, Rita ;
Rambaldi, Mirella ;
Varoli, Lucilla ;
Lannigan, Deborah ;
Smith, Jeff ;
Scudiero, Dominic ;
Kondapaka, Sudhir ;
Shoemaker, Robert H. .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2011, 46 (09) :4311-4323
[10]   Synthesis and biological evaluation of imidazo[2,1-b]thiazole-benzimidazole conjugates as microtubule-targeting agents [J].
Baig, Mirza Feroz ;
Nayak, V. Lakshma ;
Budaganaboyina, Prasad ;
Mullagiri, Kishore ;
Sunkari, Satish ;
Gour, Jitendra ;
Kamal, Ahmed .
BIOORGANIC CHEMISTRY, 2018, 77 :515-526
1234