Antibiotic efficacy in vivo predicted by in vitro activity

被引：15
作者：
Mattie, H [1 ]
机构：
[1] Leiden Univ, Med Ctr, Dept Infect Dis, NL-2300 RC Leiden, Netherlands
来源：
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2000年 / 14卷 / 02期
关键词：
in vitro; in vivo; E-max;
D O I：
10.1016/S0924-8579(99)00145-4
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
A brief overview of arguments found in the literature is presented to apply the E-max concept to experimental studies of antibiotics as well as to their clinical application. It may turn out to be more flexible than schedules based on arbitrary parameters that have the disadvantage that they have to be proven in each individual situation. (C) 2000 Elsevier Science B.V. and International Society of Chemotherapy. All rights reserved.
引用
收藏
页码：91 / 98
页数：8
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