Alterations of the retinoblastoma and p16 pathway correlate with promoter methylation in malignant fibrous histiocytomas

被引：0

作者：

Brinck, Ulrich

Schlott, Thilo

Stoerber, Steffi

Stachura, Jerzy

Bortkiewicz, Pawel

Nagel, Wolf-Dieter

Hasse, Frank Michael

Cordon-Cardo, Carlos

Fischer, Goesta

Korabiowska, Monika

机构：

[1] Univ Gottingen, Acad Hosp, Wilhelmshaven, Germany

[2] Univ Gottingen, Ctr Pathol, D-3400 Gottingen, Germany

[3] Jagiellonian Univ, Dept Pathol, Krakow, Poland

[4] Adam Mickiewicz Univ Poznan, Eth Ctr, Poznan, Poland

[5] Bathildis Hosp, Dept Orthopaed Surg, Bad Pyrmont, Germany

[6] Herzogin Elisabeth Heim, Dept Surg, Braunschweig, Germany

[7] Mem Sloan Kettering Canc Ctr, Div Mol Pathol, New York, NY 10021 USA

来源：

ANTICANCER RESEARCH | 2006年 / 26卷 / 5A期

关键词：

fibrous histiocytoma; pRb pathway; p16; promoter; methylation;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent reports indicate that the alterations in the p16 and pRb pathways can influence tumour progression and poor prognosis in several tumours. The objective of this study was to analyse p16 and pRb expression in 161 patients with malignant fibrous histiocytomas (MFH). By immunohistochemistry, p16 and pRb were demonstrated in 25% and 56% of MFH, respectively. Cox regression analysis demonstrated an independent prognostic influence of both genes. Generally, the loss of p16 and pRb expression correlated with poorer prognosis. Promoter methylation of p16 was found in 16142 of p16 negative MFH and of pRb in 2/42 of pRb-negative MFH. It can be concluded that p16 and pRb alterations play an important role in the progression of soft tissue sarcomas.

引用

页码：3461 / 3465

页数：5

共 31 条

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[3]

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