STATs: Transcriptional control and biological impact

被引：2594
作者：
Levy, DE
Darnell, JE
机构：
[1] Rockefeller Univ, Mol Cell Biol Lab, New York, NY 10021 USA
[2] NYU, Sch Med, Dept Pathol, New York, NY 10016 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2002年 / 3卷 / 09期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nrm909
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Extracellular proteins bound to cell-surface receptors can change nuclear gene expression patterns in minutes, with far-reaching consequences for development, cell growth and homeostasis. The signal transducer and activator of transcription (STAT) proteins are among the most well studied of the latent cytoplasmic signal-dependent transcription-factor pathways. In addition to several roles in normal cell decisions, dysregulation of STAT function contributes to human disease, making the study of these proteins an important topic of current research.
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页码：651 / 662
页数：12
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