Prevalence of interstitial pneumonia suggestive of COVID-19 at 18F-FDG PET/CT in oncological asymptomatic patients in a high prevalence country during pandemic period: a national multi-centric retrospective study

被引：13

作者：

Albano, Domenico ^{[1
,2
]}

Bertagna, Francesco ^{[1
,2
]}

Alongi, Pierpaolo ^{[3
]}

Baldari, Sergio ^{[4
]}

Baldoncini, Alfonso ^{[5
]}

Bartolomei, Mirco ^{[6
]}

Boccaletto, Franco ^{[7
]}

Boero, Michele ^{[8
]}

Borsatti, Eugenio ^{[9
]}

Bruno, Andrea ^{[10
]}

Burroni, Luca ^{[11
]}

Capoccetti, Francesca ^{[12
]}

Castellani, Massimo ^{[13
]}

Cervino, Anna Rita ^{[14
]}

Chierichetti, Franca ^{[15
]}

Ciarmiello, Andrea ^{[16
]}

Corso, Angelo ^{[17
]}

Cuocolo, Alberto ^{[18
]}

De Rimini, Maria Luisa ^{[19
]}

Deandreis, Desiree ^{[20
]}

Dottorini, Massimo Eugenio ^{[21
]}

Esposito, Filomena ^{[22
]}

Farsad, Mohsen ^{[23
]}

Gasparini, Massimo ^{[24
]}

Grana, Chiara Maria ^{[25
]}

Gregianin, Michele ^{[26
]}

Guerra, Luca ^{[27
,28
]}

Loreti, Fabio ^{[29
]}

Lupi, Andrea ^{[30
]}

Martino, Gianluigi ^{[31
]}

Milan, Elisa ^{[7
]}

Modoni, Sergio ^{[32
]}

Morbelli, Silvia ^{[33
,34
]}

Muni, Alfredo ^{[35
]}

Nicolai, Emanuele ^{[36
]}

Palumbo, Barbara ^{[21
,37
]}

Papa, Sergio ^{[38
]}

Papaleo, Alberto ^{[39
]}

Pellerito, Riccardo ^{[40
]}

Poti, Carlo ^{[41
]}

Romano, Pasquale ^{[42
]}

Rossetti, Claudio ^{[43
]}

Rossini, Pierluigi ^{[44
]}

Rubini, Giuseppe ^{[45
]}

Ruffini, Livia ^{[46
]}

Sacchetti, Gianmauro ^{[47
]}

Savelli, Giordano ^{[48
]}

Schiavariello, Saverio ^{[49
]}

Sciagra, Roberto ^{[50
]}

Sciuto, Rosa ^{[51
]}

机构：

[1] Univ Brescia, Nucl Med, Brescia, Italy

[2] ASST Spedali Civili Brescia, Brescia, Italy

[3] Fdn Ist G Giglio, Unit Nucl Med, I-90015 Cefalu, Italy

[4] Univ Messina, Dept Biomed & Dent Sci & Morphofunct Imaging, Nucl Med Unit, I-98125 Messina, Italy

[5] Osped San Donato, Nucl Med Dept, Arezzo, Italy

[6] Azienda Osped Univ Ferrara, Nucl Med Dept, Ferrara, Italy

[7] Treviso Hosp, Nucl Med Dept, Treviso, Italy

[8] ARNAS G Brotzu, Nucl Med Unit, Cagliari, Italy

[9] IRCCS CRO, Nucl Med, Aviano, Italy

[10] ASST Papa Giovanni XXIII, Dept Nucl Med, Bergamo, Italy

[11] Ospedali Riuniti Torrette Hosp, Dept Nucl Med, Ancona, Italy

[12] Macerata Hosp, ASUR Marche AV3, Nucl Med Unit, Serv Dept, Macerata, Italy

[13] Fdn IRCCS Ca Grande Osped Maggiore Policlin, Nucl Med Dept, Milan, Italy

[14] Veneto Inst Oncol IOV IRCCS, Nucl Med Unit, Padua, Italy

[15] Santa Chiara Hosp, Nucl Med, Trento, Italy

[16] S Andrea Hosp, Nucl Med Unit, La Spezia, Italy

[17] St Anna Hosp, Dept Nucl Med, Como, Italy

[18] Univ Naples Federico II, Dept Adv Biomed Sci, Via Pansini 5, I-80131 Naples, Italy

[19] Monaldi Hosp, AO Ospedali Colli, Nucl Med Unit, Naples, Italy

[20] Univ Turin, Div Nucl Med, Dept Med Sci, AOU Citta Salute & Sci, I-10126 Turin, Italy

[21] Osped S Maria Misericordia, Dept Diagnost Imaging, Nucl Med Unit, Perugia, Italy

[22] Neuromed, Nucl Med, Pozzilli, Italy

[23] Cent Hosp Bolzano, Nucl Med, Bolzano, Italy

[24] IRCCS MultiMed Sesto San Giovanni, Dept Nucl Med, Milan, Italy

[25] IRCCS, European Inst Oncol, Div Nucl Med, Milan, Italy

[26] Veneto Inst Oncol IOV IRCCS, Nucl Med Unit, Castelfranco Veneto, Italy

[27] Univ Milano Bicocca, Nucl Med, Monza, Italy

[28] ASST Osped San Gerardo, Monza, Italy

[29] S Maria Hosp, Nucl Med Unit, Terni, Italy

[30] Osped S Bortolo, Div Nucl Med, Vicenza, Italy

[31] SS Annunziata Hosp, Dept Radiol & Clin Radiotherapy, Unit Nucl Med, Chieti, Italy

[32] Univ Hosp Ospedali Riuniti, Nucl Med Dept, Foggia, Italy

[33] IRCCS Osped Policlin San Martino, Genoa, Italy

[34] Univ Genoa, Dept Hlth Sci DISSAL, Genoa, Italy

[35] Azienda Osped SS Antonio & Biagio & Cesare Arrigo, Nucl Med Dept, Alessandria, Italy

[36] IRCCS SDN, Naples, Italy

[37] Univ Perugia, Sect Nucl Med & Hlth Phys, Dept Med & Surg, Perugia, Italy

[38] CDI Ctr Diagnost Italiano, Unit Diagnost Imaging & Stereotact Radiosurg, Via St Bon 20, I-20147 Milan, Italy

[39] S Croce & Carle Hosp Cuneo, Nucl Med Dept, Cuneo, Italy

[40] Mauriziano Hosp, Dept Nucl Med, Turin, Italy

[41] Aosta Reg Hosp, Unit Nucl Med, Aosta, Italy

[42] Studio Radiol Guidonia, Dept Nucl Med, Guidonia, Italy

[43] ASST Grande Osped Metropolitano Niguarda, Nucl Med, Milan, Italy

[44] Azienda Socio Sanitaria Terr Mantova Osped C Poma, Nucl Med, Mantua, Italy

[45] Univ Bari, Dept Interdisciplinary Med, Nucl Med Unit, AOU Policlin, Bari, Italy

[46] Azienda Osped Univ Parma, Nucl Med Unit, Parma, Italy

[47] AOU Maggiore Carita, Nucl Med Dept, Novara, Italy

[48] Fdn Poliambulanza, Nucl Med Dept, Brescia, Italy

[49] ASM Matera, Nucl Med Unit, Matera, Italy

[50] Univ Florence, Dept Expt & Clin Biomed Sci Mario Serio, Nucl Med Unit, Florence, Italy

来源：

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | 2021年 / 48卷 / 09期

关键词：

F-18-FDG PET; CT; COVID-19; Interstitial pneumonia; SARS-CoV-2; Asymptomatic; Incidental findings;

D O I：

10.1007/s00259-021-05219-0

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Purpose To assess the presence and pattern of incidental interstitial lung alterations suspicious of COVID-19 on fluorine-18-fluorodeoxyglucose positron emission tomography (PET)/computed tomography (CT) ([F-18]FDG PET/CT) in asymptomatic oncological patients during the period of active COVID-19 in a country with high prevalence of the virus. Methods This is a multi-center retrospective observational study involving 59 Italian centers. We retrospectively reviewed the prevalence of interstitial pneumonia detected during the COVID period (between March 16 and 27, 2020) and compared to a pre-COVID period (January-February 2020) and a control time (in 2019). The diagnosis of interstitial pneumonia was done considering lung alterations of CT of PET. Results Overall, [F-18]FDG PET/CT was performed on 4008 patients in the COVID period, 19,267 in the pre-COVID period, and 5513 in the control period. The rate of interstitial pneumonia suspicious for COVID-19 was significantly higher during the COVID period (7.1%) compared with that found in the pre-COVID (5.35%) and control periods (5.15%) (p < 0.001). Instead, no significant difference among pre-COVID and control periods was present. The prevalence of interstitial pneumonia detected at PET/CT was directly associated with geographic virus diffusion, with the higher rate in Northern Italy. Among 284 interstitial pneumonia detected during COVID period, 169 (59%) were FDG-avid (average SUVmax of 4.1). Conclusions A significant increase of interstitial pneumonia incidentally detected with [F-18]FDG PET/CT has been demonstrated during the COVID-19 pandemic. A majority of interstitial pneumonia were FDG-avid. Our results underlined the importance of paying attention to incidental CT findings of pneumonia detected at PET/CT, and these reports might help to recognize early COVID-19 cases guiding the subsequent management.

引用

页码：2871 / 2882

页数：12

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