Superoxide dismutase mimetics: Synthesis and structure-activity relationship study of MnTBAP analogues

被引：70

作者：

Gauuan, PJF

Trova, MP

Gregor-Boros, L

Bocckino, SB

Crapo, JD

Day, BJ

机构：

[1] Albany Mol Res Inc, Albany, NY 12212 USA

[2] Incara Inc, Res Triangle Pk, NC 27709 USA

[3] Natl Jewish Med & Res Ctr, Denver, CO 80206 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2002年 / 10卷 / 09期

关键词：

D O I：

10.1016/S0968-0896(02)00153-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Carboxylic ester and amide-substituted analogues of [5,10.15.20-tetrakis(4-carboxyphenyl)-porphyrinato]manganese(Ill) chloride (MnTBAP) were synthesized and assayed as potential superoxide dismutase (SOD) mimetics. The tetraester analogues 4a and 4b were found to have comparable SOD activity to the known SOD mimetic MnTBAP, while amides 4c-4e exhibited reduced SOD activity, In the substituted methyl benzoate;acid and disubstituted porphyrin series. analogues 12c, 12f and 12m were found to have comparable to improved SOD activity relative to MnTBAP and analogues 12j, 13a, and 13d exhibited improved activity in both the SOD and thiobarbituric acid reactive species (TBARS) assays relative to MnTBAP. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：3013 / 3021

页数：9

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