Terpenes from Euphorbia antiquorum and Their in Vitro Anti-HIV Activity

被引：22

作者：

Dong, Miao ^{[1
]}

Chen, Xuan-Qin ^{[1
]}

Chen, Chin-Ho ^{[2
]}

Li, Rong-Tao ^{[1
]}

机构：

[1] Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650500, Yunnan, Peoples R China

[2] Duke Univ, Med Ctr, 10 Duke Med Circle, Durham, NC 27710 USA

来源：

CHEMISTRY & BIODIVERSITY | 2018年 / 15卷 / 05期

基金：

中国国家自然科学基金;

关键词：

diterpenes; triterpenes; Euphorbia antiquorum; anti-HIV; INGOL-TYPE DITERPENES; LATEX; CONSTITUENTS; TRITERPENES; INHIBITION; ASSIGNMENT; ACTIVATION; KANSUI; ESTER;

D O I：

10.1002/cbdv.201700560

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three new compounds (1 - 3), including two euphane type triterpenes, 24,24-dimethoxy-25,26,27-trinoreuphan-3-ol (1) and (24S)-24-hydroperoxyeupha-8,25-dien-3-ol (2), and an ent-atisine diterpene, ent-atisane-3,16,17-triol (3), were isolated from an acetone extract of the stems of Euphorbia antiquorum, together with eight known diterpenes (4 - 11). The structures of compounds (1 - 11) were elucidated using NMR and MS spectroscopic methods. Compound 7 showed moderate activity against HIV-1 replication in vitro (EC50 = 1.38 m).

引用

页数：7

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