2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles-O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase) (vol 18, pg 6171, 2008)

被引：0

作者：

Warmus, Joseph S. ^{[1
]}

Flamme, Cathlin ^{[1
]}

Zhang, Lu Yan ^{[1
]}

Barrett, Stephen ^{[1
]}

Bridges, Alexander ^{[1
]}

Chen, Huifen ^{[3
]}

Gowan, Richard ^{[2
]}

Kaufman, Michael ^{[1
]}

Sebolt-Leopold, Judy ^{[2
]}

Leopold, Wilbur ^{[2
]}

Merriman, Ronald ^{[2
]}

Ohren, Jeffrey ^{[3
]}

Pavlovsky, Alexander ^{[3
]}

Przybranowski, Sally ^{[2
]}

Tecle, Haile ^{[1
]}

Valik, Heather ^{[2
]}

Whitehead, Christopher ^{[3
]}

Zhang, Erli ^{[3
]}

机构：

[1] Pfizer Global Res & Dev, Dept Chem, Ann Arbor, MI 48105 USA

[2] Pfizer Global Res & Dev, Dept Oncol Pharmacol, Ann Arbor, MI 48105 USA

[3] Pfizer Global Res & Dev, Discovery Technol Struct & Analyt Sci, Ann Arbor, MI 48105 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 13期

关键词：

D O I：

10.1016/j.bmcl.2008.10.135

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：3695 / 3695

页数：1

共 1 条

[1] 2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles-O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase) [J].

Warmus, Joseph S. ;

Flamme, Cathlin ;

Zhang, Lu Yan ;

Barrett, Stephen ;

Bridges, Alexander ;

Chen, Huifen ;

Gowan, Richard ;

Kaufman, Michael ;

Sebolt-Leopold, Judy ;

Leopold, Wilbur ;

Merriman, Ronald ;

Ohren, Jeffrey ;

Pavlovsky, Alexander ;

Przybranowski, Sally ;

Tecle, Haile ;

Valik, Heather ;

Whitehead, Christopher ;

Zhang, Erli .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (23) :6171-6174

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