Spectroscopic studies of copper(II) and iron(II) complexes of adriamycin

被引：42

作者：

Feng, M ^{[1
]}

Yang, YL ^{[1
]}

He, PG ^{[1
]}

Fang, YZ ^{[1
]}

机构：

[1] E China Normal Univ, Dept Chem, Shanghai 200062, Peoples R China

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2000年 / 56卷 / 03期

关键词：

spectroscopic studies; adriamycin; copper(II) and iron(II) complexes;

D O I：

10.1016/S1386-1425(99)00157-2

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

The complexes of adriamycin (ADM) with Cu(II) and Fe(II) have been studied by visible absorption, circular dichroism (CD) and fluorescence spectra, respectively. In Tris buffer at pH 7.0, either metal ions forms a single species with adriamycin: Cu(ADM)(2) or Fe(ADM)(3). Interaction of these two complexes with various biological molecules has been examined. It is shown that some amino acids, glutathione and albumin are able to remove the Cu(II) ion from Cu(II)-ADM complex, releasing the free drug. However, Fe(II)-ADM keeps in an undissociated form under the same conditions. The possibility of Fe(II)-ADM as a new alternative drug has been discussed. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：581 / 587

页数：7

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