The first 50 live births after autologous oocyte vitrification in France

被引:10
作者
Anzola, Any Beltran [1 ,2 ]
Pauly, Vanessa [2 ,3 ]
Geoffroy-Siraudin, Cendrine [1 ]
Gervoise-Boyer, Marie-Jose [1 ]
Montjean, Debbie [1 ]
Boyer, Pierre [1 ]
机构
[1] Hop St Joseph, Serv Med & Biol Reprod, F-13008 Marseille, France
[2] Aix Marseille Univ, Dept Sante Publ & Malad Chron, Fac Med, Unite Rech EA 3279, F-13005 Marseille, France
[3] Assistance Publ Hop Marseille, Serv Informat Med, F-13009 Marseille, France
关键词
Vitrification; Autologous oocytes; Children health; Retrospective study; IN-VITRO FERTILIZATION; EMBRYO-TRANSFER; PERINATAL OUTCOMES; CHILDREN BORN; ASSISTED REPRODUCTION; SINGLETONS BORN; CLEAVAGE-STAGE; COHORT; FROZEN; CRYOPRESERVATION;
D O I
10.1007/s10815-015-0603-2
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The study aims to describe the newborn health parameters of the 50 first children conceived after autologous oocyte vitrification in France. The 50 children born after autologous oocyte vitrification/warming cycle (VAO children) have been retrospectively compared with 364 children conceived by micromanipulation using freshly recovered non-vitrified oocytes (ICSI children). Children included in the study were born between 2011 and 2015. Maternal characteristics (age, body mass index, smoking habits), obstetric outcomes (diabetes, hypertension, placenta previa, parity, mode of delivery), and perinatal outcome (twinning, sex, birth weight, macrosomia, birth defects) were analyzed. The generalized estimating equation for correlated data was performed to evaluate perinatal outcomes and caesarean section. No statistically significant difference was found between VAO children and ICSI children, even after adjusting confounding factors (low birth weigh odds ratio (OR) 0.8, 95 % confident interval (CI) 0.3-2.2, adjusted (AOR) 0.5, 95 % CI 0.2-1.7; large for gestational age OR 1.5, 95 % CI 0.3-7.0, AOR 1.6, 95 % CI 0.3-7.5; birth defects OR 0.4, 95 % CI 0.1-3.2, AOR 0.5, 95 % CI 0.1-3.7; caesarean section OR 1.8, 95 % CI 0.9-3.4, AOR 1.8, 95 % CI 0.9-3.7). According to our results, newborn health parameters of children conceived in our center by micromanipulation using vitrified/warmed autologous oocytes seem not to be different from children born after micromanipulation on freshly recovered oocytes.
引用
收藏
页码:1781 / 1787
页数:7
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