Retrospective investigation of mesalamine intolerance in patients with ulcerative colitis

被引：6

作者：

Minagawa, Yuki ^{[1
]}

Uchiyama, Kazuhiko ^{[1
]}

Takagi, Tomohisa ^{[1
]}

Mizushima, Katsura ^{[1
]}

Asaeda, Kohei ^{[1
]}

Kajiwara-Kubota, Mariko ^{[1
]}

Kashiwagi, Saori ^{[1
]}

Hotta, Yuma ^{[1
]}

Tanaka, Makoto ^{[1
]}

Inoue, Ken ^{[1
]}

Dohi, Osamu ^{[1
]}

Okayama, Tetsuya ^{[1
]}

Yoshida, Naohisa ^{[1
]}

Katada, Kazuhiro ^{[1
]}

Kamada, Kazuhiro ^{[1
]}

Ishikawa, Takeshi ^{[1
]}

Yasuda, Hiroaki ^{[1
]}

Konishi, Hideyuki ^{[1
]}

Naito, Yuji ^{[2
]}

Itoh, Yoshito ^{[1
]}

机构：

[1] Kyoto Prefectural Univ Med, Mol Gastroenterol & Hepatol, 465 Kajii Cho,Hirokoji Kawaramachi Kamigyo Ku, Kyoto 6028566, Japan

[2] Kyoto Prefectural Univ Med, Dept Human Immunol & Nutr Sci, 465 Kajii Cho,Hirokoji Kawaramachi Kamigyo Ku, Kyoto 6028566, Japan

来源：

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION | 2022年 / 71卷 / 03期

关键词：

mesalamine; intolerance; ulcerative colitis; CRP; LYMPHOCYTE-TRANSFORMATION TEST; SALICYLATE-INDUCED EXACERBATION; 5-AMINOSALICYLIC ACID; PERICARDIAL-EFFUSION; ACUTE-PANCREATITIS; ADVERSE REACTIONS; MESALAZINE; SULFASALAZINE; DIAGNOSIS; CHILD;

D O I：

10.3164/jcbn.22-33

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Mesalamine is a key drug in the treatment of ulcerative colitis (UC) for both induction and maintenance therapy. On the other hand, it is known that there are some cases of mesalamine intolerance that are difficult to distinguish from symptoms due to aggravation of UC. The aim of this study is to investigate the clinical characteristic of mesalamine intolerance in UC. A retrospective, observational study was conducted. We enrolled 31 patients who were diagnosed as mesalamine intolerance between April 2015 to March 2020. We examined clinical features, time to onset, drug types of mesalamine, DLST positive rate, colonoscopy findings, disease activity, and clinical course after diagnosis. The average dose of mesalamine was 3.69 g and DLST-positive was 57.1%. Within the first 2 weeks from the start of mesalamine, 51.6% showed symptoms of intolerance. The serum CRP level was relatively high at 10.0 mg/dl in 53.6% of the cases. There was no difference in clinical background, symptoms, or laboratory findings between patients with DLST-positive and negative. In this study, we clarified the clinical characteristics of mesalamine intolerant patients, and found no difference in the clinical background or success rate of desensitization therapy between positive and negative DLST cases.

引用

页码：249 / 254

页数：6

共 40 条

[1] ACUTE-PANCREATITIS SECONDARY TO 5-AMINOSALICYLIC ACID IN A CHILD WITH ULCERATIVE-COLITIS [J].