Avascular Necrosis of Femoral Head as the Initial Manifestation of CML

被引：8

作者：

Kumar, Suresh ^{[1
]}

Bansal, Deepak ^{[1
]}

Prakash, Mahesh ^{[2
]}

Sharma, Prashant ^{[3
]}

机构：

[1] Postgrad Inst Med Educ & Res, Adv Pediat Ctr, Dept Pediat, Hematol Oncol Unit, Chandigarh 160012, India

[2] Postgrad Inst Med Educ & Res, Dept Radiodiag & Imaging, Chandigarh 160012, India

[3] Postgrad Inst Med Educ & Res, Dept Hematol, Chandigarh 160012, India

来源：

PEDIATRIC HEMATOLOGY AND ONCOLOGY | 2014年 / 31卷 / 06期

关键词：

acute lymphoblastic leukemia; bone scan; chronic myeloid leukemia; hyperviscosity; MRI; osteonecrosis; ACUTE LYMPHOBLASTIC-LEUKEMIA; CHRONIC MYELOGENOUS LEUKEMIA; OSTEONECROSIS; COMPLICATION; CHILDREN; DISEASE; BONE;

D O I：

10.3109/08880018.2013.831961

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A 12-year-old female is reported who presented with right hip pain for 6 months. With massive splenohepatomegaly and leukocytosis, CML was suspected and confirmed on bone-marrow examination and cytogenetics. Further investigations confirmed avascular necrosis (AVN) of the right femoral head. CML was treated by hydroxyurea, followed by imatinib. AVN was managed conservatively; patient demonstrated progressive improvement, though a mild limp in the gait was persisting at 22 months. AVN as the initial manifestation of CML is a rarity. Leukostasis is considered to be the pathophysiological mechanism. In view of the rarity, a case is reported, along with compilation of previously reported cases.

引用

页码：568 / 573

页数：6

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