Chiral separation of β-blockers after derivatization with (-)-menthyl chloroformate by reversed-phase high performance liquid chromatography

被引：9

作者：

Kim, KH ^{[1
]}

Choi, PW

Hong, SP

Kim, HJ

机构：

[1] Kangweon Natl Univ, Coll Pharm, Chunchon 200701, Kangwon, South Korea

[2] Kyung Hee Univ, Coll Pharm, Seoul 130701, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 1999年 / 22卷 / 06期

关键词：

chiral derivatization; beta-blocker; resolution; (-)-menthyl chloroformate;

D O I：

10.1007/BF02975333

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Optimum conditions of chiral derivatization reaction of beta-blockers(acebutolol, arotinolol, betaxolol, bisoprolol, celiprolol, meloprolol and pindolol) with (-)-menthyl chloroformate were investigated for the resolution by HPLC. With more than 30 times molar excess of (-)-menthyl chloroformate chiral derivatization reactions were completed within one hour at room temperature except arotinolol and celiprolol. Diastereomeric derivatives of beta-blockers were well resolved on the ODS column using acetonitrile-methanol-water as a mobile phase.

引用

页码：608 / 613

页数：6

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