Human Cathelicidin LL-37 Resistance and Increased Daptomycin MIC in Methicillin-Resistant Staphylococcus aureus Strain USA600 (ST45) Are Associated with Increased Mortality in a Hospital Setting

被引：19
作者：
Sakoulas, George [1 ]
Guram, Kripa [1 ]
Reyes, Katherine [2 ]
Nizet, Victor [1 ]
Zervos, Marcus [2 ]
机构：
[1] Univ Calif San Diego, Sch Med, La Jolla, CA 92093 USA
[2] Wayne State Univ, Sch Med, Henry Ford Hosp, Detroit, MI USA
来源：
JOURNAL OF CLINICAL MICROBIOLOGY | 2014年 / 52卷 / 06期
关键词：
PLATELET MICROBICIDAL PROTEIN; REDUCED SUSCEPTIBILITY; PERSISTENT BACTEREMIA; VANCOMYCIN; INFECTIONS; PEPTIDES; LEVEL; TIME;
D O I：
10.1128/JCM.00189-14
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Bacteremia caused by methicillin-resistant Staphylococcus aureus (MRSA) USA600 has been associated with increased patient mortality. We found that USA600 MRSA exhibited significantly increased resistance to human cathelicidin LL-37 killing and daptomycin MIC creep compared to non-USA600 MRSA. Virulent health care-associated MRSA strains may coevolve innate host defense peptide and antibiotic resistances.
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收藏
页码：2172 / 2174
页数：3
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