Efficient Protection of Retina By Tyrosine-Mutated Self-Complementary AAV2 Vector Encoding BDNF in a Rat Retinal Ischemic Injury Model

被引：0
|
作者：
Igarashi, Tsutomu [1 ,2 ]
Miyake, Koichi [2 ]
Kobayashi, Maika [1 ,2 ]
Takahashi, Kazuhisa [1 ,2 ]
Miyake, Noriko [2 ]
Iijima, Osamu [2 ]
Nakamoto, Kenji [1 ]
Hirai, Yukihiko [2 ]
Shimada, Takashi [2 ]
Takahashi, Hiroshi [1 ]
机构：
[1] Nippon Med Sch, Tokyo 113, Japan
[2] Nippon Med Sch, Dept Biochem & Mol Biol, Div Gene Therapy Res, Ctr Adv Med Technol, Tokyo 113, Japan
来源：
MOLECULAR THERAPY | 2014年 / 22卷
关键词：
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
127
引用
收藏
页码：S47 / S47
页数：1
相关论文
共 8 条
  • [1] Tyrosine-mutated AAV2 (Y730, 500, 444F) mediated BDNF rescued inner retina in rat retinal ischemic injury model
    Kobayashi, M.
    Igarashi, T.
    Miyake, K.
    Miyake, N.
    Nakamoto, K.
    Hirai, Y.
    Takahashi, H.
    Okada, T.
    HUMAN GENE THERAPY, 2016, 27 (11) : A122 - A123
  • [2] Tyrosine-mutated AAV2 mediated BDNF gene therapy attenuates retinal ischemic injuries in rats
    Igarashi, Tsutomu
    Miyake, Koichi
    Kobayashi, Maika
    Takahashi, Kazuhisa
    Miyake, Noriko
    Iijima, Osamu
    Nakamoto, Kenji
    Hirai, Yukihiko
    Shimada, Takashi
    Takahashi, Hiroshi
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2014, 55 (13)
  • [3] AAV retinal transduction in a large animal model species: Comparison of a self-complementary AAV2/5 with a single-stranded AAV2/5 vector
    Petersen-Jones, S. M.
    Bartoe, J. T.
    Fischer, A. J.
    Scott, M.
    Boye, S. L.
    Chiodo, V.
    Hauswirth, W. W.
    MOLECULAR VISION, 2009, 15 (194-95): : 1835 - 1842
  • [4] Systemic Delivery of Self-Complementary AAV2/9 Vectors in Adult Mice Results in Efficient Transduction of the Retina
    Bemelmans, A.
    Duque, S.
    Riviere, C.
    Marais, T.
    Astord, S.
    Desrosiers, M.
    Sahel, J. -A.
    Volt, T.
    Barkats, M.
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2010, 51 (13)
  • [5] Rapid Correction of Ornithine Transcarbamylase Deficiency (OTCD) in OTCD Mouse Model by Self-Complementary AAV2/8 Vector
    Wang, Huan
    Wang, Lili
    Morizono, Hiroki
    Jones, David
    Bell, Peter L.
    Dorante, A. Avilan
    Gao, Guangping
    Batshaw, Mark L.
    Wilson, James M.
    MOLECULAR THERAPY, 2009, 17 : S69 - S69
  • [6] RAPID CORRECTION OF ORNITHINE TRANSCARBAMYLASE DEFICIENCY (OTCD) IN AN OTCD MOUSE MODEL USING A SELF-COMPLEMENTARY AAV2/8 VECTOR
    Jones, D. J.
    Wang, H.
    Bell, P.
    Avilan-Dorante, A.
    Gao, G.
    Batshaw, M. L.
    Wilson, J. M.
    Wang, L.
    Morizono, H.
    MOLECULAR GENETICS AND METABOLISM, 2009, 98 (1-2) : 147 - 147
  • [7] Tyrosine triple mutated AAV2-BDNF gene therapy in an inner retinal injury model induced by intravitreal injection of N-methyl-D-aspartate (NMDA)
    Shiozawa, Asaka Lee
    Igarashi, Tsutomu
    Kobayashi, Maika
    Nakamoto, Kenji
    Kameya, Shuhei
    Fujishita, Shigeto
    Takahashi, Hiroshi
    Okada, Takashi
    MOLECULAR VISION, 2020, 26 : 409 - 422
  • [8] Tyrosine Triple Mutated AAV2-BDNF Gene Therapy to Treat an Inner Retinal Injury Model Induced by Intravitreal Injection of N-methyl-D-Aspartate (NMDA)
    Shiozawa, Asaka Lee
    Igarashi, Tsutomu
    Kobayashi, Maika
    Nakamoto, Kenji
    Kameya, Shuhei
    Fujishita, Shigeto
    Takahashi, Hiroshi
    Okada, Takashi
    MOLECULAR THERAPY, 2020, 28 (04) : 319 - 319
1