Circulating fibrosis markers, eosinophil cationic protein and eosinophil protein X in patients with Wuchereria bancrofti infection:: Association with clinical status

被引:4
作者
Esterre, P.
Plichart, C.
Huin-Blondey, M. O.
Nguyen, L. N.
Hartmann, D.
Guerret, S.
Reimert, C. M.
Ricard-Blum, S.
机构
[1] Pharmaceut Fac, Lyon, France
[2] Danish Bilharziasis Lab, Charlottenlund, Denmark
[3] Univ Lyon 1, CNRS, Inst Biol & Chim Prot, UMR 5086, F-69365 Lyon, France
[4] Inst Rech Med Malarde, Immunol Unit, F-98713 Tahiti, France
[5] Inst Rech Med Malarde, Epidemiol Unit, F-98713 Tahiti, France
关键词
lymphatic filariasis; fibrosis markers; eosinophil proteins; French Polynesia;
D O I
10.1051/parasite/2006132165
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
We measured the concentrations of several circulating fibrosis markers (type I collagen I, type III procollagen, hyaluronan) and eosinophil granule proteins (ECP and EPX) in lymphatic filariasis patients to investigate their relationship with clinical, parasitological and immunological data. This study was conducted in Polynesian patients with various stages of the disease (acute lymphangitis, chyluria, hydrocoele, elephantiasis), a closely related microbial lymphangitis and endemic controls. We observed modifications of the different markers in this pathology. Serum type I collagen and PIIINP were decreased. Serum hyaluronan, linked to perilymphatic granulomatous inflammation, was significantly increased in acute lymphangitis and elephantiasis patients. Serum ECP was also increased, at the limit of significance in our sample, in elephantiasis patients. These two last markers, already validated in another helminth disease, schistosomiasis, have potential interest in terms of follow-up of morbidity in these parasitic diseases.
引用
收藏
页码:165 / 170
页数:6
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