Spiro-oxindoles via bimetallic [Pd(0)/Ag(I)] catalytic intramolecular Heck-1,3-dipolar cycloaddition cascade reactions

被引：43

作者：

Grigg, R ^{[1
]}

Millington, EL ^{[1
]}

Thornton-Pett, M ^{[1
]}

机构：

[1] Univ Leeds, Sch Chem, MIDAS Ctr, Leeds LS2 9JT, W Yorkshire, England

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 14期

关键词：

D O I：

10.1016/S0040-4039(02)00331-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The combination of an intramolecular Heck reaction with a subsequent Ag(l) catalysed imine --> azomethine ylide --> cycloaddition cascade is described for the formation of novel spiro-oxindoles. The reaction proceeds regiospecifically with good to excellent stereoselectivity and creates two new rings, three bonds and three stereocentres. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2605 / 2608

页数：4

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