Multiple subsets of regulatory T-cells

被引:0
作者
Kupriyanov, S., V [1 ]
Sinitsky, A., I [1 ]
Dolgushin, I. I. [1 ]
机构
[1] South Ural State Med Univ, 64 Vorovskogo Str, Chelyabinsk 454092, Russia
来源
BYULLETEN SIBIRSKOY MEDITSINY | 2020年 / 19卷 / 03期
关键词
regulatory T-lymphocytes; immunological tolerance; memory Treg; effector Treg; central Treg; tissuespecific Treg; MEMORY; ANTIGEN; POPULATION; MAINTENANCE; EXPRESSION; INDUCTION; IL-35;
D O I
10.20538/1682-0363-2020-3-144-155
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Regulatory T-lymphocytes play a central role in the immunological tolerance system. To date, existence of many different subpopulations of regulatory T-cells have been described. However, a number of questions related to the function, differentiation, and homeostasis of these subpopulations in a body remain unclear. Interactions between the previously discovered pairs of helper and regulatory T-lymphocytes require further study. The main topic is identification and establishment of the functions of regulatory memory cells. Interstitial migration of activated regulatory T-lymphocytes is also a promising direction. In this review, we summarized the main findings in multiple subsets of regulatory T-lymphocytes, discussed unclear data that will require further studies, and showed an application for regulatory T-lymphocytes in medicine.
引用
收藏
页码:144 / 155
页数:12
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