Decarboxylative Arylation of α-Amino Acids via Photoredox Catalysis: A One-Step Conversion of Biomass to Drug Pharmacophore

被引：461
|
作者：
Zuo, Zhiwei [1 ]
MacMillan, David W. C. [1 ]
机构：
[1] Princeton Univ, Merck Ctr Catalysis, Princeton, NJ 08544 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 136卷 / 14期
关键词：
ELECTROCHEMICAL OXIDATION; COORDINATION-COMPOUNDS; IRIDIUM(III); RADICALS; LIGHT; TRANSFORMATIONS; COMPLEXES; ALDEHYDES; SALTS;
D O I：
10.1021/ja501621q
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The direct decarboxylative arylation of alpha-amino acids has been achieved via visible light-mediated photoredox catalysis. This method offers rapid entry to prevalent benzylic amine architectures from an abundant biomass, specifically alpha-amino acid precursors. Significant substrate scope is observed with respect to both the amino acid and arene components.
引用
收藏
页码：5257 / 5260
页数：4
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