Decarboxylative Arylation of α-Amino Acids via Photoredox Catalysis: A One-Step Conversion of Biomass to Drug Pharmacophore

被引：479

作者：

Zuo, Zhiwei ^{[1
]}

MacMillan, David W. C. ^{[1
]}

机构：

[1] Princeton Univ, Merck Ctr Catalysis, Princeton, NJ 08544 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 136卷 / 14期

关键词：

ELECTROCHEMICAL OXIDATION; COORDINATION-COMPOUNDS; IRIDIUM(III); RADICALS; LIGHT; TRANSFORMATIONS; COMPLEXES; ALDEHYDES; SALTS;

D O I：

10.1021/ja501621q

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The direct decarboxylative arylation of alpha-amino acids has been achieved via visible light-mediated photoredox catalysis. This method offers rapid entry to prevalent benzylic amine architectures from an abundant biomass, specifically alpha-amino acid precursors. Significant substrate scope is observed with respect to both the amino acid and arene components.

引用

页码：5257 / 5260

页数：4

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