Highly Enantioselective Direct Aldol Reactions Catalyzed by Proline Derivatives Based on a Calix[4]arene Scaffold in the Presence of Water

被引：27

作者：

Li, Zheng-Yi ^{[1
]}

Chen, Jia-Wen ^{[1
]}

Wang, Leyong ^{[1
]}

Pan, Yi ^{[2
]}

机构：

[1] Nanjing Univ, Key Lab Mesoscop Chem, Minist Educ, Sch Chem & Chem Engn, Nanjing 210093, Peoples R China

[2] Nanjing Univ, State Key Lab Coordinat Chem, Nanjing 210093, Peoples R China

来源：

SYNLETT | 2009年 / 14期

关键词：

proline; calix[4]arene; organocatalyst; aldol reaction; water; OCTOPUS-TYPE CALIXARENE; N-PROLYLSULFONAMIDE; ORGANIC-REACTIONS; AQUEOUS-MEDIUM; ORGANOCATALYSTS; ALDEHYDES; EFFICIENT; KETONES; DIHYDROXYACETONE; ABILITY;

D O I：

10.1055/s-0029-1217710

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of proline-derived organocatalysts based on a calix[4]arene scaffold have been developed to catalyze direct aldol reactions in the presence of water. Under the optimal conditions, high yields (up to >99%). good enantioselectivities (up to >99% ee) and diastereoselectivities (up to 90: 10) were obtained.

引用

页码：2356 / 2360

页数：5

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