Optimal management of thymic malignancies: current perspectives

被引：21

作者：

Drevet, Gabrielle ^{[1
]}

Collaud, Stephane ^{[1
]}

Tronc, Francois ^{[1
]}

Girard, Nicolas ^{[2
,3
]}

Maury, Ean-Michel ^{[1
,3
,4
]}

机构：

[1] Hosp Civils Lyon, Louis Pradel Hosp, Dept Thorac Surg Lung & Heart Lung Transplantat, Lyon, France

[2] Inst Thorax Curie Montsouris, Inst Curie, F-75248 Paris 05, France

[3] Reseau Tumeurs THYM & Canc RYTHMIC, Natl Expert Ctr Thym Malignancies, Lyon, France

[4] Univ Claude Bernard Lyon I, Univ Lyon, IVPC UMR754 INRA, EPHE, Lyon, France

来源：

CANCER MANAGEMENT AND RESEARCH | 2019年 / 11卷

关键词：

thymic epithelial tumors; thymomas; thymic carcinomas; surgery; radiation; chemotherapy; LONG-TERM SURVIVAL; LYMPH-NODE MAP; ASSISTED THORACOSCOPIC THYMECTOMY; FORTHCOMING 8TH EDITION; TUMORS STAGING PROJECT; EPITHELIAL TUMORS; POSTOPERATIVE RADIOTHERAPY; SURGICAL RESECTION; PLEURAL RECURRENCE; PROGNOSTIC-FACTORS;

D O I：

10.2147/CMAR.S171683

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Thymic epithelial tumors (TETs) belong to orphan oncology. The incidence of TETs is about 1.3-3.2 cases per million worldwide. Following pathology, evolution and prognosis are variable. The World Health Organization classification distinguishes thymomas and thymic carcinomas. TETs are composed of thymic epithelial tumoral cells and normal lymphocytes. The mean age at diagnosis is 50-60 years-old. There are no identified risk factors. TETs are frequently associated with paraneoplastic syndromes as myasthenia gravis. The complete R-0 surgical resection is the most significant prognosis factor on survival. In 2010, the French National Institute of Cancer labeled the RYTHMIC network as a specific tumor board including thoracic surgeons, oncologist, and radiation therapist to define standard of care for the management of TETs. The aim of the review was to update knowledge to optimize the standard of care.

引用

页码：6803 / 6814

页数：12

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