Effects of aging on B cell function

被引：101
|
作者：
Frasca, Daniela [1 ]
Blomberg, Bonnie B. [1 ]
机构：
[1] Univ Miami, Miller Sch Med, Dept Microbiol & Immunol, Miami, FL 33101 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2009年 / 21卷 / 04期
关键词：
INDUCED CYTIDINE DEAMINASE; AGED MICE DIFFER; IG CLASS SWITCH; REPERTOIRE DIVERSITY; BACTERIAL-ANTIGENS; ANTIBODY-RESPONSE; GERMINAL-CENTERS; V-H; PHOSPHORYLCHOLINE-ANTIBODY; GENE HYPERMUTATION;
D O I：
10.1016/j.coi.2009.06.001
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Ability to make an optimal immune response to vaccines and infectious agents declines with age in humans and animal models. Recent advances have shown intrinsic B cell defects in aged mice and humans, including decreases in Ig class switch recombination (CSR), activation-induced cytidine deaminase (AID), and E47 transcription factor. Effects on somatic hypermutation (SHM) have been varied depending on the system studied. Increase of AID in mice has shown improved CSR but not SHM. The reported microarray analysis of human B cell subsets may now be used to delineate B cell defects with aging and all the advances presented should lead to selecting agents for improved immune response in the elderly.
引用
收藏
页码：425 / 430
页数：6
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