Tumor cell-derived microparticles polarize M2 tumor-associated macrophages for tumor progression

被引：102

作者：

Ma, Ruihua ^{[1
]}

Ji, Tiantian ^{[1
]}

Chen, Degao ^{[2
,3
,4
]}

Dong, Wenqian ^{[2
,3
,4
]}

Zhang, Huafeng ^{[2
,3
,4
]}

Yin, Xiaonan ^{[2
,3
,4
]}

Ma, Jingwei ^{[2
,3
,4
]}

Liang, Xiaoyu ^{[2
,3
,4
]}

Zhang, Yi ^{[2
,3
,4
]}

Shen, Guanxin ^{[5
]}

Qin, Xiaofeng ^{[6
,7
]}

Huang, Bo ^{[1
,2
,3
,4
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Biochem & Mol Biol, Wuhan 430074, Peoples R China

[2] Chinese Acad Med Sci, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing 100730, Peoples R China

[3] Chinese Acad Med Sci, Inst Basic Med Sci, Dept Immunol, Beijing 100730, Peoples R China

[4] Peking Union Med Coll, Beijing 100021, Peoples R China

[5] Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Immunol, Wuhan 430074, Peoples R China

[6] Chinese Acad Med Sci, Ctr Syst Med, Beijing 100730, Peoples R China

[7] Suzhou Inst Syst Med, Suzhou, Peoples R China

来源：

ONCOIMMUNOLOGY | 2016年 / 5卷 / 04期

基金：

中国国家自然科学基金;

关键词：

cGAS; STING pathway; M2 tumor-associated macrophages; polarization; tumor cell-derived microparticles; tumor progression; CYCLIC GMP-AMP; SUPPRESSOR-CELLS; PLATELET MICROPARTICLES; SELF-RENEWAL; STEM-CELLS; CANCER; METASTASIS; RESISTANCE; RESPONSES; LYSOSOME;

D O I：

10.1080/2162402X.2015.1118599

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Despite identification of macrophages in tumors (tumor-associated macrophages, TAM) as potential targets for cancer therapy, the origin and function of TAM in the context of malignancy remain poorly characterized. Here, we show that microparticles (MPs), as a by-product, released by tumor cells act as a general mechanism to mediate M2 polarization of TAM. Taking up tumor MPs by macrophages is a very efficient process, which in turn results in the polarization of macrophages into M2 type, not only leading to promoting tumor growth and metastasis but also facilitating cancer stem cell development. Moreover, we demonstrate that the underlying mechanism involves the activation of the cGAS/STING/TBK1/STAT6 pathway by tumor MPs. Finally, in addition to murine tumor MPs, we show that human counterparts also possess consistent effect on human M2 polarization. These findings provide new insights into a critical role of tumor MPs in remodeling of tumor microenvironment and better understanding of the communications between tumors and macrophages.

引用

页数：12

共 57 条

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