IL-6 in diabetes and cardiovascular complications

被引：145

作者：

Qu, Dan ^{[1
]}

Liu, Jian ^{[1
]}

Lau, Chi Wai ^{[1
]}

Huang, Yu ^{[1
]}

机构：

[1] Chinese Univ Hong Kong, Inst Vasc Med, Shenzhen Res Inst, Li Ka Shing Inst Hlth Sci, Hong Kong, Hong Kong, Peoples R China

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2014年 / 171卷 / 15期

关键词：

CORONARY-HEART-DISEASE; SOLUBLE INTERLEUKIN-6 RECEPTOR; ALPHA CONVERTING-ENZYME; NECROSIS-FACTOR-ALPHA; SMOOTH-MUSCLE-CELLS; RHEUMATOID-ARTHRITIS; SKELETAL-MUSCLE; TNF-ALPHA; ENDOTHELIAL DYSFUNCTION; INFLAMMATORY CYTOKINES;

D O I：

10.1111/bph.12713

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

IL-6 is a pleiotropic cytokine that participates in normal functions of the immune system, haematopoiesis, metabolism, as well as in the pathogenesis of metabolic and cardiovascular diseases. Both pro- and anti-inflammatory roles of IL-6 have been described, which are distinguished by different cascades of signalling transduction, namely classic and trans-signalling. The present review summarizes the basic principles of IL-6 signalling and discusses its roles in diabetes and associated cardiovascular complications, with emphasis on the different outcomes mediated by the two modes of IL-6 signalling and the value of developing therapeutic strategies to specifically target the deleterious trans-signalling of IL-6.

引用

页码：3595 / 3603

页数：9

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