Applying "Gold Standards" to In-Vitro-Derived Germ Cells

被引：69

作者：

Handel, Mary Ann ^{[1
]}

Eppig, John J. ^{[1
]}

Schimenti, John C. ^{[2
]}

机构：

[1] Jackson Lab, Bar Harbor, ME 04609 USA

[2] Cornell Univ, Ithaca, NY 14853 USA

来源：

CELL | 2014年 / 157卷 / 06期

关键词：

EMBRYONIC STEM-CELLS; METABOLIC COOPERATIVITY; MOUSE; MEIOSIS; OOCYTES; FATE; OOGENESIS; GENETICS; OVARIES; MICE;

D O I：

10.1016/j.cell.2014.05.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Germ cells are the ultimate stem cells, and reports of their in vitro derivation generate excitement due to potential applications in reproductive medicine. To date, there is no firm evidence that meiosis, the hallmark of gametogenesis, can be faithfully replicated outside of the gonad. We propose benchmarks for evaluating in vitro derivation of germ cells, facilitating realization of their potential.

引用

收藏

页码：1257 / 1261

页数：5

相关论文

共 22 条

[1] GENETICS OF MEIOSIS AND RECOMBINATION IN MICE [J].

Bolcun-Filas, Ewelina ;

Schimenti, John C. .

INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY, VOL 298, 2012, 298 :179-+

[2] Oocyte differentiation is genetically dissociable from meiosis in mice [J].

Dokshin, Gregoriy A. ;

Baltus, Andrew E. ;

Eppig, John J. ;

Page, David C. .

NATURE GENETICS, 2013, 45 (08) :877-U289

[3] Evidence That a Defective Spindle Assembly Checkpoint Is Not the Primary Cause of Maternal Age-Associated Aneuploidy in Mouse Eggs [J].

Duncan, Francesca E. ;

Chiang, Teresa ;

Schultz, Richard M. ;

Lampson, Michael A. .

BIOLOGY OF REPRODUCTION, 2009, 81 (04) :768-776

[4] Complete Meiosis from Human Induced Pluripotent Stem Cells [J].

Eguizabal, C. ;

Montserrat, N. ;

Vassena, R. ;

Barragan, M. ;

Garreta, E. ;

Garcia-Quevedo, L. ;

Vidal, F. ;

Giorgetti, A. ;

Veiga, A. ;

Belmonte, J. C. Izpisua .

STEM CELLS, 2011, 29 (08) :1186-1195

[5] Genetics of mammalian meiosis: regulation, dynamics and impact on fertility [J].

Handel, Mary Ann ;

Schimenti, John C. .

NATURE REVIEWS GENETICS, 2010, 11 (02) :124-136

[6] Offspring from Oocytes Derived from in Vitro Primordial Germ Cell-like Cells in Mice [J].

Hayashi, Katsuhiko ;

Ogushi, Sugako ;

Kurimoto, Kazuki ;

Shimamoto, So ;

Ohta, Hiroshi ;

Saitou, Mitinori .

SCIENCE, 2012, 338 (6109) :971-975

[7] Female mice lack adult germ-line stem cells but sustain oogenesis using stable primordial follicles [J].

Lei, Lei ;

Spradling, Allan C. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (21) :8585-8590

[8] Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells [J].

Lister, Ryan ;

Pelizzola, Mattia ;

Kida, Yasuyuki S. ;

Hawkins, R. David ;

Nery, Joseph R. ;

Hon, Gary ;

Antosiewicz-Bourget, Jessica ;

O'Malley, Ronan ;

Castanon, Rosa ;

Klugman, Sarit ;

Downes, Michael ;

Yu, Ruth ;

Stewart, Ron ;

Ren, Bing ;

Thomson, James A. ;

Evans, Ronald M. ;

Ecker, Joseph R. .

NATURE, 2011, 471 (7336) :68-U84

[9] Mitosis-meiosis and sperm-oocyte fate decisions are separable regulatory events [J].

Morgan, Clinton T. ;

Noble, Daniel ;

Kimble, Judith .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (09) :3411-3416

[10] Induction of mouse germ-cell fate by transcription factors in vitro [J].

Nakaki, Fumio ;

Hayashi, Katsuhiko ;

Ohta, Hiroshi ;

Kurimoto, Kazuki ;

Yabuta, Yukihiro ;

Saitou, Mitinori .

NATURE, 2013, 501 (7466) :222-+