BK Polyomavirus: Clinical Aspects, Immune Regulation, and Emerging Therapies

被引：168
作者：
Ambalathingal, George R. [1 ,4 ]
Francis, Ross S. [2 ,4 ]
Smyth, Mark J. [1 ,3 ,4 ]
Smith, Corey [1 ]
Khanna, Rajiv [1 ]
机构：
[1] QIMR Berghofer Med Res Inst, Tumour Immunol Lab, QIMR Berghofer Ctr Immunotherapy & Vaccine Dev, Herston, Qld, Australia
[2] Princess Alexandra Hosp, Dept Nephrol, Woolloongabba, Qld, Australia
[3] Berghofer Med Res Inst, Immunol Canc & Infect Lab, Herston, Qld, Australia
[4] Univ Queensland, Fac Med, Brisbane, Qld, Australia
来源：
CLINICAL MICROBIOLOGY REVIEWS | 2017年 / 30卷 / 02期
关键词：
B cell responses; T cells; T cell immunity; immunotherapy; natural killer cells; pathogenesis; transplant; virus; LARGE-T-ANTIGEN; VIRUS-ASSOCIATED NEPHROPATHY; KIDNEY-TRANSPLANT RECIPIENTS; RENAL-ALLOGRAFT RECIPIENTS; MINOR CAPSID PROTEINS; LARGE TUMOR-ANTIGEN; HEMORRHAGIC CYSTITIS; ADOPTIVE TRANSFER; JC VIRUS; INTRAVENOUS IMMUNOGLOBULIN;
D O I：
10.1128/CMR.00074-16
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
BK polyomavirus (BKV) causes frequent infections during childhood and establishes persistent infections within renal tubular cells and the uroepithelium, with minimal clinical implications. However, reactivation of BKV in immunocompromised individuals following renal or hematopoietic stem cell transplantation may cause serious complications, including BKV-associated nephropathy (BKVAN), ureteric stenosis, or hemorrhagic cystitis. Implementation of more potent immunosuppression and increased posttransplant surveillance has resulted in a higher incidence of BKVAN. Antiviral immunity plays a crucial role in controlling BKV replication, and our increasing knowledge about host-virus interactions has led to the development of improved diagnostic tools and clinical management strategies. Currently, there are no effective antiviral agents for BKV infection, and the mainstay of managing reactivation is reduction of immunosuppression. Development of immune-based therapies to combat BKV may provide new and exciting opportunities for the successful treatment of BKV-associated complications.
引用
收藏
页码：503 / 528
页数：26
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