Coronary microvascular dysfunction: an update

被引：602

作者：

Crea, Filippo ^{[1
]}

Camici, Paolo G. ^{[2
,3
]}

Merz, Cathleen Noel Bairey ^{[4
]}

机构：

[1] Univ Cattolica Sacro Cuore, Inst Cardiol, Dept Cardiovasc Sci, I-00187 Rome, Italy

[2] Ist Sci San Raffaele, Dept Cardiothorac Vasc Med, I-20132 Milan, Italy

[3] Univ Vita Salute San Raffaele, Milan, Italy

[4] Cedars Sinai Med Ctr, Cedars Sinai Heart Inst, Barbra Streisand Womens Heart Ctr, Los Angeles, CA 90048 USA

来源：

EUROPEAN HEART JOURNAL | 2014年 / 35卷 / 17期

关键词：

Acute coronary syndromes; Coronary microvascular dysfunction; Myocardial diseases; Coronary microvascular obstruction; Stable angina; CARDIAC SYNDROME-X; ACUTE MYOCARDIAL-INFARCTION; ISCHEMIA-SYNDROME-EVALUATION; SYNDROME EVALUATION WISE; POSITRON-EMISSION-TOMOGRAPHY; LEFT-VENTRICULAR FUNCTION; CARDIOVASCULAR MAGNETIC-RESONANCE; IDIOPATHIC DILATED CARDIOMYOPATHY; CONVERTING ENZYME-INHIBITION; NO-REFLOW PHENOMENON;

D O I：

10.1093/eurheartj/eht513

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Many patients undergoing coronary angiography because of chest pain syndromes, believed to be indicative of obstructive atherosclerosis of the epicardial coronary arteries, are found to have normal angiograms. In the past two decades, a number of studies have reported that abnormalities in the function and structure of the coronary microcirculation may occur in patients without obstructive atherosclerosis, but with risk factors or with myocardial diseases as well as in patients with obstructive atherosclerosis; furthermore, coronary microvascular dysfunction (CMD) can be iatrogenic. In some instances, CMD represents an epiphenomenon, whereas in others it is an important marker of risk or may even contribute to the pathogenesis of cardiovascular and myocardial diseases, thus becoming a therapeutic target. This review article provides an update on the clinical relevance of CMD in different clinical settings and also the implications for therapy.

引用

页码：1101 / +

页数：15

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