Gut microbiota is a factor of risk for obesity and type 2 diabetes

被引：2

作者：

Demidova, T. Y. ^{[1
]}

Lobanova, K. G. ^{[1
]}

Oinotkinova, O. S. ^{[1
,2
,3
]}

机构：

[1] Pirogov Russian Natl Res Med Univ, Moscow, Russia

[2] Lomonosov Moscow State Univ, Moscow, Russia

[3] Res Inst Hlth Org & Med Management, Moscow, Russia

来源：

TERAPEVTICHESKII ARKHIV | 2020年 / 92卷 / 10期

关键词：

gut microbiota; short-chain fatty acids; obesity; type; 2; diabetes; HYDROGEN-SULFIDE; GLUCOSE-METABOLISM; BARIATRIC SURGERY; DIETARY FIBER; SECRETION; PREVENTION; METAGENOME; RESISTANCE; PROBIOTICS; DIVERSITY;

D O I：

10.26442/00403660.2020.10.000778

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Gut microbiota (GM) is a set of bacteria which colonize the gastrointestinal tract. GM and its active metabolites take part in intestinal and hepatic gluconeogenesis, in the synthesis of incretin hormones, and affect the regulation of appetite. Thus, GM and its metabolites participate in the homeostasis of carbohydrates and fats. An imbalance in the set of the intestinal flora and a disturbance of the production of active metabolites sharply increases the risk of developing obesity and type 2 diabetes. There are conflicting data in the literature on the role of specific microorganisms in the development of metabolic disorders. Research is needed to identify specific types of bacteria and their active metabolites which affect the development of obesity and type 2 diabetes.

引用

页码：97 / 104

页数：8

共 50 条

[21] A Metabolite Perspective on the Involvement of the Gut Microbiota in Type 2 Diabetes
Fu, Yifeng
Li, Siying
Xiao, Yunhua
Liu, Gang
Fang, Jun
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (19)
[22] Type 2 Diabetes Mellitus Associated with Obesity (Diabesity). The Central Role of Gut Microbiota and Its Translational Applications
Ortega, Miguel A.
Fraile-Martinez, Oscar
Naya, Irene
Garcia-Honduvilla, Natalio
Alvarez-Mon, Melchor
Bujan, Julia
Asunsolo, Angel
de la Torre, Basilio
NUTRIENTS, 2020, 12 (09) : 1 - 29
[23] Gut-Microbial Metabolites, Probiotics and Their Roles in Type 2 Diabetes
Zhai, Lixiang
Wu, Jiayan
Lam, Yan Y.
Kwan, Hiu Yee
Bian, Zhao-Xiang
Wong, Hoi Leong Xavier
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (23)
[24] The role of gut microbiota in the development of type 1, type 2 diabetes mellitus and obesity
Ningwen Tai
F. Susan Wong
Li Wen
Reviews in Endocrine and Metabolic Disorders, 2015, 16 : 55 - 65
[25] Relationship between gut microbiota, probiotics, and type 2 diabetes mellitus
Salgaco, Mateus Kawata
Segura Oliveira, Liliane Garcia
Costa, Giselle Nobre
Bianchi, Fernanda
Sivieri, Katia
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2019, 103 (23-24) : 9229 - 9238
[26] Healthy dietary pattern and their corresponding gut microbiota profile are linked to a lower risk of type 2 diabetes, independent of the presence of obesity
Diaz-Rizzolo, D. A.
Kostov, B.
Lopez-Siles, M.
Serra, A.
Colungo, C.
Gonzalez-de-Paz, L.
Martinez-Medina, M.
Siso-Almirall, A.
Gomis, R.
CLINICAL NUTRITION, 2020, 39 (02) : 524 - 532
[27] Role of Gut Microbiota in Obesity, Type 2 Diabetes and Alzheimer's Disease
Naseer, Muhammad I.
Bibi, Fehmida
Alqahtani, Mohammed H.
Chaudhary, Adeel G.
Azhar, Esam I.
Kamal, Mohammad A.
Yasir, Muhammad
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2014, 13 (02) : 305 - 311
[28] Do nutrient-gut-microbiota interactions play a role in human obesity, insulin resistance and type 2 diabetes?
Diamant, M.
Blaak, E. E.
de Vos, W. M.
OBESITY REVIEWS, 2011, 12 (04) : 272 - 281
[29] Role of gut microbiota in type 2 diabetes pathophysiology
Gurung, Manoj
Li, Zhipeng
You, Hannah
Rodrigues, Richard
Jump, Donald B.
Morgun, Andrey
Shulzhenko, Natalia
EBIOMEDICINE, 2020, 51
[30] THE NEW VIEWS ON THE STATE OF THE GUT MICROBIOTA IN OBESITY AND DIABETES MELLITUS TYPE 2 (vol 22, pg 253, 2019)
Pokrovskaya, Elena V.
Shamkhalova, Minara S.
Shestakova, Marina V.
DIABETES MELLITUS, 2019, 22 (04): : 403 - 404

← 1 2 3 4 5 →