Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScope®-Global Registry for Emerging Fungal Infections

被引：23

作者：

Salmanton-Garcia, Jon ^{[1
,2
]}

Koehler, Philipp ^{[1
,2
,3
]}

Kindo, Anupma ^{[4
]}

Falces-Romero, Iker ^{[5
]}

Garcia-Rodriguez, Julio ^{[5
]}

Racil, Zdenek ^{[6
,7
,8
]}

Chen, Sharon C-A ^{[9
,10
]}

Klimko, Nikolai ^{[11
]}

Desoubeaux, Guillaume ^{[12
,13
]}

Thompson, George R., III ^{[14
,15
]}

Benitez-Penuela, Miguel-Angel ^{[16
]}

Rodriguez, Jose-Yesid ^{[16
]}

Sheppard, Donald C. ^{[17
,18
,19
]}

Hoenigl, Martin ^{[20
,21
,22
,23
]}

Le Govic, Yohann ^{[24
]}

Badali, Hamid ^{[25
]}

Baddley, John W. ^{[26
,27
,28
]}

Chander, Jagdish ^{[29
]}

Ingram, Paul R. ^{[30
,31
]}

Pakstis, Diana L. ^{[32
]}

Mellinghoff, Sibylle C. ^{[1
,2
]}

Atici, Serkan ^{[33
]}

Cesaro, Simone ^{[34
]}

Chakrabarti, Arunaloke ^{[35
]}

Dupont, Damien ^{[36
,37
]}

Gonzalez, Gloria M. ^{[38
]}

Hatvani, Lorant ^{[39
,40
]}

Herbrecht, Raoul ^{[41
,42
]}

Klyasova, Galina ^{[43
]}

Lass-Florl, Cornelia ^{[44
]}

Mares, Mihai ^{[45
]}

Mullane, Kathleen ^{[46
]}

Vinh, Donald C. ^{[47
]}

Wisplinghoff, Hilmar ^{[48
,49
,50
]}

Lackner, Michaela ^{[44
]}

Cornely, Oliver A. ^{[1
,2
,51
,52
,53
]}

Seidel, Danila ^{[1
,2
]}

机构：

[1] Univ Cologne, Fac Med, Herderstr 52-54, D-50931 Cologne, Germany

[2] Univ Hosp Cologne, Dept Internal Med 1, Ctr Integrated Oncol Aachen Bonn Cologne Duesseld, Excellence Ctr Med Mycol ECMM, Herderstr 52-54, D-50931 Cologne, Germany

[3] Univ Cologne, Cologne Excellence Cluster Cellular Stress Respon, Cologne, Germany

[4] Sri Ramachandra Med Coll & Res Inst, Dept Microbiol, SRIHER, Chennai, Tamil Nadu, India

[5] Univ Hosp La Paz, Clin Microbiol & Parasitol Dept, Madrid, Spain

[6] Masaryk Univ, Dept Internal Med Hematol & Oncol, Brno, Czech Republic

[7] Univ Hosp Brno, Brno, Czech Republic

[8] Inst Hematol & Blood Transfus, Prague, Czech Republic

[9] Westmead Hosp, Ctr Dis & Microbiol Lab Serv, New South Wales Hlth Pathol, ICPMR, Sydney, NSW, Australia

[10] Univ Sydney, Sydney, NSW, Australia

[11] Mechnikov North Western State Med Univ, St Petersburg, Russia

[12] CHU Tours, Parasitol Mycol Med Tropicale, Tours, France

[13] Univ Tours, Ctr Etud Pathol Resp, Unite Inserm U1100, Tours, France

[14] Univ Calif Davis, Dept Internal Med Div Infect Dis, Davis Med Ctr, Sacramento, CA 95817 USA

[15] Univ Calif Davis Med Ctr, Dept Med Microbiol & Immunol, Davis Med Ctr, Sacramento, CA 95817 USA

[16] Rosario Pumarejo Lopez Hosp, Ctr Microbiol Res Cesar CIMCE, Med Clin LTDA, Laura Daniela Clin, Valledupar, Colombia

[17] McGill Univ, Dept Med, Div Infect Dis, Res Inst,Hlth Ctr, Montreal, PQ, Canada

[18] McGill Univ, Dept Microbiol, Div Infect Dis, Res Inst,Hlth Ctr, Montreal, PQ, Canada

[19] McGill Univ, Dept Immunol, Div Infect Dis, Res Inst,Hlth Ctr, Montreal, PQ, Canada

[20] Univ Calif San Diego, Clin & Translat FungalWorking Grp, La Jolla, CA 92093 USA

[21] Univ Calif San Diego, Dept Med, Div Infect Dis & Global Publ Hlth, San Diego, CA 92093 USA

[22] Med Univ Graz, ECMM Excellence Ctr Clin Mycol, Sect Infect Dis & Trop Med, Graz, Austria

[23] Med Univ Graz, Div Pulmonol, Graz, Austria

[24] Univ Hosp Ctr, Parasitol Mycol Unit, Fort De France, Martinique, France

[25] Mazandaran Univ Med Sci, Invas Fungi Res Ctr, Communicable Dis Inst, Sari, Iran

[26] Univ Alabama Birmingham, Dept Internal Med, Div Infect Dis, Birmingham, AL USA

[27] Birmingham VA Med Ctr, Med Serv, Birmingham, AL USA

[28] Univ Maryland, Sch Med, Inst Human Virol, Baltimore, MD 21201 USA

[29] Govt Med Coll & Hosp, Dept Microbiol, Chandigarh, India

[30] Royal Perth Hosp, Dept Infect Dis, Perth, WA, Australia

[31] Univ Western Australia, Sch Pathol & Lab Med, Perth, WA, Australia

[32] Univ Pittsburgh, Dept Med, Div Infect Dis, Pittsburgh, PA USA

[33] Okan Univ, Dept Pediat, Div Pediat Infect Dis, Sch Med, Istanbul, Turkey

[34] Azienda Osped Univ Integrata Verona, Dept Mother & Child, Pediat Hematol Oncol, Verona, Italy

[35] Postgrad Inst Med Educ & Res, Dept Med Microbiol, Res, Chandigarh, India

[36] Hosp Civils Lyon, Inst Agents Infectieux, Hop Croix Rousse, Parasitol Mycol, Lyon, France

[37] Univ Claude Bernard Lyon 1, Ctr Rech Neurosci Lyon, Integrat Physiol Brain Arousal Syst, INSERM U1028,CNRS UMR 5292,Fac Med, Lyon, France

[38] Univ Autonoma Nuevo Leon, Sch Med, Dept Microbiol, San Nicolas De Los Garza, Nuevo Leon, Mexico

[39] MTA SZTE Lendulet Mycobiome Res Grp, Szeged, Hungary

[40] Univ Szeged, Fac Sci & Informat, Dept Microbiol, Szeged, Hungary

[41] Hop Univ Strasbourg, Dept Oncol & Hematol, Strasbourg, France

[42] Univ Strasbourg, INSERM, UMR S1113, IRFAC, Strasbourg, France

[43] Natl Res Ctr Hematol, Epartment Clin Microbiol Mycol & Antibiot Therapy, Moscow, Russia

[44] Med Univ Innsbruck, Inst Hyg & Med Microbiol, Innsbruck, Austria

[45] Ion Ionescu Brad Univ, Lab Antimicrobial Chemotherapy, Iasi, Romania

[46] Univ Chicago, Dept Med, Sect Infect Dis & Global Hlth, 5841 S Maryland Ave, Chicago, IL 60637 USA

[47] McGill Univ, Res Inst, Infect Dis & Immun Global Hlth Program, Hlth Ctr, Montreal, PQ, Canada

[48] Wisplinghoff Labs, Cologne, Germany

[49] Univ Cologne, Inst Med Microbiol, Cologne, Germany

[50] Witten Herdecke Univ, Inst Virol & Microbiol, Witten, Germany

来源：

JOURNAL OF INFECTION | 2020年 / 81卷 / 05期

关键词：

Rare; Invasive fungal infections; Registry; Mold; Yeast; JOINT CLINICAL GUIDELINES; TRANSPLANT RECIPIENTS; SCEDOSPORIUM SPP; PHEOHYPHOMYCOSIS; MANAGEMENT; DIAGNOSIS; SURVEILLANCE; MULTICENTER; FUSARIOSIS; RESPONSES;

D O I：

10.1016/j.jinf.2020.08.015

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Objectives: Emerging invasive fungal infections (IFI) have become a notable challenge. Apart from the more frequently described fusariosis, lomentosporiosis, mucormycosis, scedosporiosis, and certain dematiaceae or yeasts, little is known about extremely rare IFI. Methods: Extremely rare IFI collected in the FungiScope (R) registry were grouped as Dematiaceae, Hypocreales, Saccharomycetales, Eurotiales, Dermatomycetes, Agaricales, and Mucorales. Results: Between 2003 and June 2019, 186 extremely rare IFI were documented in FungiScope (R). Dematiaceae (35.5%), Hypocreales (23.1%), Mucorales (11.8%), and Saccharomycetales (11.3%) caused most IFI. Most patients had an underlying malignancy (38.7%) with acute leukemia accounting for 50% of cancers. Dissemination was observed in 26.9% of the patients. Complete or partial clinical response rate was 68.3%, being highest in Eurotiales (82.4%) and in Agaricales (80.0%). Overall mortality rate was 29.3%, ranging from 11.8% in Eurotiales to 50.0% in Mucorales. Conclusions: Physicians are confronted with a complex variety of fungal pathogens, for which treatment recommendations are lacking and successful outcome might be incidental. Through an international consortium of physicians and scientists, these cases of extremely rare IFI can be collected to further investigate their epidemiology and eventually identify effective treatment regimens. (C) 2020 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

引用

页码：802 / 815

页数：14

共 41 条

[1] ESCMID† and ECMM‡ joint clinical guidelines for the diagnosis and management of rare invasive yeast infections [J].

Arendrup, M. C. ;

Boekhout, T. ;

Akova, M. ;

Meis, J. F. ;

Cornely, O. A. ;

Lortholary, O. .

CLINICAL MICROBIOLOGY AND INFECTION, 2014, 20 :76-98

[2] Phaeohyphomycosis in a Tertiary Care Cancer Center [J].

Ben-Ami, Ronen ;

Lewis, Russell E. ;

Raad, Issam I. ;

Kontoyiannis, Dimitrios P. .

CLINICAL INFECTIOUS DISEASES, 2009, 48 (08) :1033-1041

[3] Population-Based Analysis of Invasive Fungal Infections, France, 2001-2010 [J].

Bitar, Dounia ;

Lortholary, Olivier ;

Le Strat, Yann ;

Nicolau, Javier ;

Coignard, Bruno ;

Tattevin, Pierre ;

Che, Didier ;

Dromer, Francoise .

EMERGING INFECTIOUS DISEASES, 2014, 20 (07) :1149-1155

[4] ESCMID and ECMM joint clinical guidelines for the diagnosis and management of systemic phaeohyphomycosis: diseases caused by black fungi [J].

Chowdhary, A. ;

Meis, J. F. ;

Guarro, J. ;

de Hoog, G. S. ;

Kathuria, S. ;

Arendrup, M. C. ;

Arikan-Akdagli, S. ;

Akova, M. ;

Boekhout, T. ;

Caira, M. ;

Guinea, J. ;

Chakrabarti, A. ;

Dannaoui, E. ;

van Diepeningen, A. ;

Freiberger, T. ;

Groll, A. H. ;

Hope, W. W. ;

Johnson, E. ;

Lackner, M. ;

Lagrou, K. ;

Lanternier, F. ;

Lass-Floerl, C. ;

Lortholary, O. ;

Meletiadis, J. ;

Munoz, P. ;

Pagano, L. ;

Petrikkos, G. ;

Richardson, M. D. ;

Roilides, E. ;

Skiada, A. ;

Tortorano, A. M. ;

Ullmann, A. J. ;

Verweij, P. E. ;

Cornely, O. A. ;

Cuenca-Estrella, M. .

CLINICAL MICROBIOLOGY AND INFECTION, 2014, 20 :47-75

[5] Schizophyllum commune as an emerging fungal pathogen: a review and report of two cases [J].

Chowdhary, A. ;

Randhawa, H. S. ;

Gaur, S. N. ;

Agarwal, K. ;

Kathuria, S. ;

Roy, P. ;

Klaassen, C. H. ;

Meis, J. F. .

MYCOSES, 2013, 56 (01) :1-10

[6] Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium [J].

Cornely, Oliver A. ;

Alastruey-Izquierdo, Ana ;

Arenz, Dorothee ;

Chen, Sharon C. A. ;

Dannaoui, Eric ;

Hochhegger, Bruno ;

Hoenigl, Martin ;

Jensen, Henrik E. ;

Lagrou, Katrien ;

Lewis, Russell E. ;

Mellinghoff, Sibylle C. ;

Mer, Mervyn ;

Pana, Zoi D. ;

Seidel, Danila ;

Sheppard, Donald C. ;

Wahba, Roger ;

Akova, Murat ;

Alanio, Alexandre ;

Al-Hatmi, Abdullah M. S. ;

Arikan-Akdagli, Sevtap ;

Badali, Hamid ;

Ben-Ami, Ronen ;

Bonifaz, Alexandro ;

Bretagne, Stephane ;

Castagnola, Elio ;

Chayakulkeeree, Methee ;

Colombo, Arnaldo L. ;

Corzo-Leon, Dora E. ;

Drgona, Lubos ;

Groll, Andreas H. ;

Guinea, Jesus ;

Heussel, Claus-Peter ;

Ibrahim, Ashraf S. ;

Kanj, Souha S. ;

Klimko, Nikolay ;

Lackner, Michaela ;

Lamoth, Frederic ;

Lanternier, Fanny ;

Lass-Floerl, Cornelia ;

Lee, Dong-Gun ;

Lehrnbecher, Thomas ;

Lmimouni, Badre E. ;

Mares, Mihai ;

Maschmeyer, Georg ;

Meis, Jacques F. ;

Meletiadis, Joseph ;

Morrissey, C. Orla ;

Nucci, Marcio ;

Oladele, Rita ;

Pagano, Livio .

LANCET INFECTIOUS DISEASES, 2019, 19 (12) :E405-E421

[7] Defining breakthrough invasive fungal infection-Position paper of the mycoses study group education and research consortium and the European Confederation of Medical Mycology [J].

Cornely, Oliver A. ;

Hoenigl, Martin ;

Lass-Florl, Cornelia ;

Chen, Sharon C-A ;

Kontoyiannis, Dimitrios P. ;

Morrissey, C. Orla ;

Thompson, George R., III .

MYCOSES, 2019, 62 (09) :716-729

[8] Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium [J].

Donnelly, J. Peter ;

Chen, Sharon C. ;

Kauffman, Carol A. ;

Steinbach, William J. ;

Baddley, John W. ;

Verweij, Paul E. ;

Clancy, Cornelius J. ;

Wingard, John R. ;

Lockhart, Shawn R. ;

Groll, Andreas H. ;

Sorrell, Tania C. ;

Bassetti, Matteo ;

Akan, Hamdi ;

Alexander, Barbara D. ;

Andes, David ;

Azoulay, Elie ;

Bialek, Ralf ;

Bradsher, Robert W., Jr. ;

Bretagne, Stephane ;

Calandra, Thierry ;

Caliendo, Angela M. ;

Castagnola, Elio ;

Cruciani, Mario ;

Cuenca-Estrella, Manuel ;

Decker, Catherine F. ;

Desai, Sujal R. ;

Fisher, Brian ;

Harrison, Thomas ;

Heussel, Claus Peter ;

Jensen, Henrik E. ;

Kibbler, Christopher C. ;

Kontoyiannis, Dimitrios P. ;

Kullberg, Bart-Jan ;

Lagrou, Katrien ;

Lamoth, Frederic ;

Lehrnbecher, Thomas ;

Loeffler, Jurgen ;

Lortholary, Olivier ;

Maertens, Johan ;

Marchetti, Oscar ;

Marr, Kieren A. ;

Masur, Henry ;

Meis, Jacques F. ;

Morrisey, C. Orla ;

Nucci, Marcio ;

Ostrosky-Zeichner, Luis ;

Pagano, Livio ;

Patterson, Thomas F. ;

Perfect, John R. ;

Racil, Zdenek .

CLINICAL INFECTIOUS DISEASES, 2020, 71 (06) :1367-1376

[9] Invasive fungal infection after heart transplantation: A 7-year, single-center experience [J].

Echenique, Ignacio A. ;

Angarone, Michael P. ;

Gordon, Robert A. ;

Rich, Jonathan ;

Anderson, Allen S. ;

McGee, Edwin C. ;

Abicht, Travis O. ;

Kang, Joseph ;

Stosor, Valentina .

TRANSPLANT INFECTIOUS DISEASE, 2017, 19 (01)

[10] Beauveria bassiana keratitis in bullous keratopathy: antifungal sensitivity testing and management [J].

Figueira, Luis ;

Pinheiro, Dolores ;

Moreira, Raul ;

Pinto, Eugenia ;

Simoes, Joana ;

Camisa, Elise ;

Torrao, Lufs ;

Palmares, Jorge ;

Falcao-Reis, Fernando .

EUROPEAN JOURNAL OF OPHTHALMOLOGY, 2012, 22 (05) :814-818

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