CYP2C9, CYP4F2, VKORC1 Gene Polymorphism in Buryat Population

被引：1
作者：
Sambyalova, A. Yu. [1 ]
Bairova, T. A. [1 ]
Belyaeva, E. V. [1 ]
Ershova, O. A. [1 ]
Sargaeva, D. S. [2 ]
Kolesnikov, S. I. [1 ,3 ]
机构：
[1] Sci Ctr Family Hlth & Human Reprod Problems, Irkutsk 664003, Russia
[2] Semashko Republican lin Hosp, Ulan Ude 670031, Russia
[3] Moscow MV Lomonosov State Univ, Moscow 119234, Russia
来源：
RUSSIAN JOURNAL OF GENETICS | 2020年 / 56卷 / 12期
关键词：
Buryat population; polymorphism; VKORC1; WARFARIN DOSAGE; VARIANTS; REQUIREMENTS; VARIABILITY; HAPLOTYPES; RS2108622; FREQUENCY; ALLELES; ROMA;
D O I：
10.1134/S1022795420120121
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The allele and genotype frequency distribution at polymorphic loci rs1799853 (430C>T) and rs1057910 (A1075C) of the CYP2C9 gene, rs2108622 (1347C>T) of the CYP4F2 gene, and rs9923231 (1639G>A) of the VKORC1 gene in the Buryat population was examined. The study involved 197 volunteers living in the Republic of Buryatia: 124 woman and 73 men, average age of 57.51 +/- 10.88 years. Genetic typing of DNA samples was performed by polymerase chain reaction (RT-PCR). The frequency of the minor alleles *2 and *3 of the CYP2C9 gene was 2.03 and 3.05%, respectively. The frequency of the allele T of the CYP4F2 gene was 31.22%; the frequency of the allele A of the VKORC1 gene was 85.28%. The obtained results could be used in the prognosis of pharmacotherapy of warfarin in the population Buryat population.
引用
收藏
页码：1496 / 1503
页数：8
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