Synthesis, characterization and antiproliferative activity of hexa arm star shaped thiosemicarbazones derived from cyclotriphosphazene core

被引：24

作者：

Machakanur, Shrinath S. ^{[1
]}

Patil, Basavaraj R. ^{[1
]}

Naik, Ganesh N. ^{[1
]}

Bakale, Raghavendra P. ^{[1
]}

Bligh, S. W. Annie ^{[2
]}

Gudasi, Kalagouda B. ^{[1
]}

机构：

[1] Karnatak Univ, Dept Chem, Dharwad 580003, Karnataka, India

[2] London Metropolitan Univ, Inst Hlth Res & Policy, London N7 8DB, England

来源：

INORGANICA CHIMICA ACTA | 2014年 / 421卷

关键词：

Cyclophosphazene; Thiosemicarbazones; Thiosemicarbazides; MCF7; PA-1; POTENTIAL ANTITUMOR AGENTS; POLYMERIC PHOSPHAZENES; SCHIFF-BASE; DERIVATIVES; INHIBITORS; SEMICARBAZONE; DENDRIMERS; CRUZAIN;

D O I：

10.1016/j.ica.2014.06.040

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A series of novel hexa-arm star shaped thiosemicarbazones with different substitutions at para positions emanating from cyclotriphosphazene core were prepared with excellent yields. The structure of all the synthesized compounds was confirmed by elemental analysis and spectroscopic methods (FT-IR, H-1, C-13, P-31 NMR, 2D HSQC and ESI-MS). The compounds were evaluated for their in vitro antiproliferative activity against breast cancer (MCF7) and ovarian cancer (PA-1) cell lines using MTT assay. The newly synthesized compounds exhibited moderate to good activity against the tested cell lines. Among them the halo substituted benzoic thiosemicarbazones were found to be more potent towards anticancer activity. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：459 / 464

页数：6

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