Cardiorenal Syndrome Pathophysiology

被引：121

作者：

Kumar, Ujjala ^{[1
]}

Wettersten, Nicholas ^{[2
]}

Garimella, Pranav S. ^{[1
]}

机构：

[1] Univ Calif San Diego, Div Nephrol Hypertens, 9500 Gilman Dr 9111H, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Div Cardiol, 9434 Med Ctr Dr, La Jolla, CA 92037 USA

来源：

CARDIOLOGY CLINICS | 2019年 / 37卷 / 03期

关键词：

Cardiorenal; Venous congestion; Intra-abdominal pressure; RAAS; Oxidative stress; Inflammatory mediators; Uremic toxins; C-REACTIVE PROTEIN; WORSENING RENAL-FUNCTION; DECOMPENSATED HEART-FAILURE; 11TH CONSENSUS CONFERENCE; CHRONIC KIDNEY-DISEASE; LOW-DOSE DOPAMINE; INDOXYL SULFATE; ANGIOTENSIN-II; OXIDATIVE STRESS; CARDIOVASCULAR MORTALITY;

D O I：

10.1016/j.ccl.2019.04.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cardiorenal syndrome commonly refers to the collective dysfunction of heart and kidney resulting in a cascade of feedback mechanism causing damage to both the organs and is associated with adverse clinical outcomes. The pathophysiology of cardiorenal syndrome is complex, multifactorial, and dynamic. Improving the understanding of disease mechanisms will aid in developing targeted pharmacologic and nonpharmacologic therapies for the management of this syndrome. This article discusses the various mechanisms involved in the pathophysiology of the cardiorenal syndrome.

引用

页码：251 / +

页数：16

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