Tenascins in stem cell niches

被引：142

作者：

Chiquet-Ehrismann, Ruth ^{[1
,2
]}

Orend, Gertraud ^{[3
,4
,5
,6
]}

Chiquet, Matthias ^{[7
]}

Tucker, Richard P. ^{[8
]}

Midwood, Kim S. ^{[9
]}

机构：

[1] Novartis Res Fdn, Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland

[2] Univ Basel, Fac Sci, CH-4003 Basel, Switzerland

[3] Inserm U1109, Microenvironm Niche Tumorigenesis & Targeted Ther, F-67200 Strasbourg, France

[4] Univ Strasbourg, F-67000 Strasbourg, France

[5] Univ Strasbourg, LabEx Medalis, F-67000 Strasbourg, France

[6] Federat Med Translat Strasbourg, F-67000 Strasbourg, France

[7] Univ Bern, Dept Orthodont & Dentofacial Orthoped, CH-3010 Bern, Switzerland

[8] Univ Calif Davis, Dept Cell Biol & Human Anat, Davis, CA 95616 USA

[9] Univ Oxford, Kennedy Inst Rheumatol, Oxford OX3 7FY, England

来源：

MATRIX BIOLOGY | 2014年 / 37卷

基金：

瑞士国家科学基金会;

关键词：

Tenascin; Stem cell niche; Development; Hematopoiesis; Inflammation; Cancer; EXTRACELLULAR-MATRIX PROTEIN; T-LYMPHOCYTE ADHESION; HUMAN BREAST-CANCER; HEMATOPOIETIC STEM; GENE-EXPRESSION; SIGNALING PATHWAYS; PUTATIVE FUNCTIONS; PROGENITOR CELLS; MURINE TENASCIN; TUMOR STROMA;

D O I：

10.1016/j.matbio.2014.01.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tenascins are extracellular matrix proteins with distinct spatial and temporal expression during development, tissue homeostasis and disease. Based on their expression patterns and knockout phenotypes an important role of tenascins in tissue formation, cell adhesion modulation, regulation of proliferation and differentiation has been demonstrated. All of these features are of importance in stem cell niches where a precise regulation of growth versus differentiation has to be guaranteed. In this review we summarize the expression and possible functions of tenascins in neural, epithelial and osteogenic stem cell niches during normal development and organ turnover, in the hematopoietic and pro-inflammatory niche as well as in the metastatic niche during cancer progression. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：112 / 123

页数：12

共 144 条

[1] Multipotent nestin-positive, keratin-negative hair-follicle bulge stem cells can form neurons [J].