Facile synthesis of Nε-(benzyl, methyl)-lysine as a building block for site-specifically lysine monomethylated peptides

被引：6

作者：

Huang, Zhi-Ping ^{[1
]}

Su, Xiao-Yang ^{[1
]}

Du, Jin-Tang ^{[1
]}

Zhao, Yu-Fen ^{[1
]}

Li, Yan-Mei ^{[1
]}

机构：

[1] Tsing Hua Univ, Dept Chem, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Minist Educ, Beijing 100084, Peoples R China

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 33期

基金：

中国国家自然科学基金;

关键词：

lysine; methylation; benzylation; monomethylated peptide;

D O I：

10.1016/j.tetlet.2006.05.190

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Facile, mild and efficient one-pot preparation of N-alpha-Fmoc-N-epsilon-(benzyl, methyl)-lysine, a building block for monomethylated peptide synthesis, was described. This building block was proved to be efficient for the synthesis of site-specifically monomethylated peptide. Benzyl group, which was incorporated by reductive benzylation and removed via catalytic hydrogenolysis, served as an excellent protecting group. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：5997 / 5999

页数：3

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