Functional connectivity and grey matter volume of the striatum in schizophrenia

被引：27

作者：

Koch, Kathrin ^{[1
,2
,3
,4
]}

Rus, Oana Georgiana ^{[1
,3
,4
]}

Reess, Tim Jonas ^{[1
,3
,4
]}

Schachtzabel, Claudia ^{[2
]}

Wagner, Gerd ^{[2
]}

Schultz, C. Christoph ^{[2
]}

Sorg, Christian ^{[1
]}

Schloesser, Ralf G. M. ^{[2
]}

机构：

[1] Tech Univ Munich, Klinikum Rechts Isar, Dept Neuroradiol, D-81675 Munich, Germany

[2] Jena Univ Hosp, Dept Psychiat & Psychotherapy, Jena, Germany

[3] Tech Univ Munich, Klinikum Rechts Isar, TUM Neuroimaging Ctr TUM NIC, D-81675 Munich, Germany

[4] Univ Munich, Bioctr, Grad Sch Syst Neurosci GSN, Munich, Germany

来源：

BRITISH JOURNAL OF PSYCHIATRY | 2014年 / 205卷 / 03期

关键词：

REWARD PREDICTION; SALIENCE NETWORK; BASAL GANGLIA; ACTIVATION; DYSFUNCTION; ANTICIPATION; CONTRIBUTE; RELEVANCE; SYSTEM; ROLES;

D O I：

10.1192/bjp.bp.113.138099

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Background Alterations in the dopaminergic reward system, predominantly the striatum, constitute core characteristics of schizophrenia. Aims Functional connectivity of the dorsal striatum during reward-related trial-and-error learning was investigated in 17 people with schizophrenia and 18 healthy volunteers and related to striatal grey matter volume and psychopathology. Method We used voxel-based morphometry and psychophysiological interaction to examine striatal volume and connectivity. Results A reduced functional connectivity between left striatum and temporo-occipital areas, precuneus and insula could be detected in the schizophrenia group. The positive correlation between grey matter volume and functional connectivity of the left striatum yielded significant results in a very similar network. Connectivity of the left striatum was negatively correlated with negative symptoms. Conclusions Present results suggest a disruption in striatal functional connectivity that is closely linked to grey matter morphometry of the striatum. Decreased connectivity between the striatum and psychopathologically relevant networks may explain the emergence of negative symptoms.

引用

页码：204 / 213

页数：10

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