Hole Transport in A-form DNA/RNA Hybrid Duplexes

被引:5
作者
Wong, Jiun Ru [1 ]
Shao, Fangwei [1 ]
机构
[1] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, 21 Nanyang Link, Singapore 637371, Singapore
来源
SCIENTIFIC REPORTS | 2017年 / 7卷
关键词
DNA CHARGE-TRANSPORT; RANGE OXIDATIVE DAMAGE; ELECTRON-TRANSFER; PROBE; DEPENDENCE; PROTEIN;
D O I
10.1038/srep40293
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
DNA/RNA hybrid duplexes are prevalent in many cellular functions and are an attractive target form for electrochemical biosensing and electric nanodevice. However the electronic conductivities of DNA/RNA hybrid duplex remain relatively unexplored and limited further technological applications. Here cyclopropyl-modified deoxyribose-and ribose-adenosines were developed to explore hole transport (HT) in both DNA duplex and DNA/RNA hybrids by probing the transient hole occupancies on adenine tracts. HT yields through both B-form and A-form double helixes displayed similar shallow distance dependence, although the HT yields of DNA/RNA hybrid duplexes were lower than those of DNA duplexes. The lack of oscillatory periods and direction dependence in HT through both helixes implied efficient hole propagation can be achieved via the hole delocalization and coherent HT over adenine tracts, regardless of the structural variations.
引用
收藏
页数:8
相关论文
共 35 条
  • [1] Adams R. L. P., 1986, BIOCH NUCL ACIDS
  • [2] DNA Charge Transport: from Chemical Principles to the Cell
    Arnold, Anna R.
    Grodick, Michael A.
    Barton, Jacqueline K.
    [J]. CELL CHEMICAL BIOLOGY, 2016, 23 (01): : 183 - 197
  • [3] Conformational gating of DNA conductance
    Artes, Juan Manuel
    Li, Yuanhui
    Qi, Jianqing
    Anantram, M. P.
    Hihath, Joshua
    [J]. NATURE COMMUNICATIONS, 2015, 6
  • [4] Distance-independent DNA charge transport across an adenine tract
    Augustyn, Katherine E.
    Genereux, Joseph C.
    Barton, Jacqueline K.
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, 46 (30) : 5731 - 5733
  • [5] Influence of intervening mismatches on long-range guanine oxidation in DNA duplexes
    Bhattacharya, PK
    Barton, JK
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (36) : 8649 - 8656
  • [6] Electrochemical detection of lesions in DNA
    Boal, AK
    Barton, JK
    [J]. BIOCONJUGATE CHEMISTRY, 2005, 16 (02) : 312 - 321
  • [7] An electrical probe of protein-DNA interactions on DNA-modified surfaces
    Boon, EM
    Salas, JE
    Barton, JK
    [J]. NATURE BIOTECHNOLOGY, 2002, 20 (03) : 282 - 286
  • [8] Redmond Red as a Redox Probe for the DNA-Mediated Detection of Abasic Sites
    Buzzeo, Marisa C.
    Barton, Jacqueline K.
    [J]. BIOCONJUGATE CHEMISTRY, 2008, 19 (11) : 2110 - 2112
  • [9] Hole trapping at N6-cyclopropyideoxyadenosine suggests a direct contribution of adenine bases to hole transport through DNA
    Dohno, C
    Ogawa, A
    Nakatani, K
    Saito, I
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (34) : 10154 - 10155
  • [10] Charge migration along the DNA duplex: Hole versus electron transport
    Elias, Benjamin
    Shao, Fangwei
    Barton, Jacqueline K.
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (04) : 1152 - +