Propolis protects pancreatic beta-cells against the toxicity of streptozotocin (STZ)

被引：29

作者：

Matsushige, K

Basnet, P

Hase, K

Kadota, S

Tanaka, K

Namba, T

机构：

[1] TOYAMA MED & PHARMACEUT UNIV,RES INST WAKAN YAKU TRADIT SINO JAPANESE MED,TOYAMA 93001,JAPAN

[2] NATL RES INST POLICE SCI,CHIYODA KU,TOKYO 102,JAPAN

来源：

PHYTOMEDICINE | 1996年 / 3卷 / 02期

关键词：

propolis; free radical scavenger; streptozotocin; interleukin-1; beta; nitric oxide;

D O I：

10.1016/S0944-7113(96)80037-7

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Propolis is a glue, prepared by honeybees from plant materials to stick their hives on the beehive wall. It has gained popularity in Japan as a healthy drink and people believe that propolis can cure inflammation, heart diseases and even diabetes and cancer. We have evaluated the beta-cell protective effect of propolis against the toxicity of streptozotocin (STZ) in rats. The water extract of propolis (PWE) completely protected beta-cell destruction against STZ toxicity. The protective effect of PWE was found to be almost equal to that of nicotinamide. PWE also inhibited the interleukin-l 1 beta (IL-1 beta) generation from human leukocytes. The free radical scavenging activity together with IL-1 beta and nitric oxide (NO) synthase inhibitory activities are thought to be the prime factors for the protective effect of PWE against STZ toxicity.

引用

页码：203 / 209

页数：7

共 24 条

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