Stereotactic radiosurgery for trigeminal schwannoma: tumor control and functional preservation

Object. To evaluate Outcome predictors after stereotactic radiosurgery (SRS) in patients with trigeminal schwannomas, the authors compared tumor control, functional preservation, and complications with tumor grade, tumor Volume, patient age, and tumor imaging characteristics. Methods. The records of 33 consecutive patients with trigeminal schwannoma treated via Gamma Knife surgery were retrospectively reviewed. The median patient age was 49.5 years (range 15.1-82.5 years). Eleven patients had undergone prior tumor resection. Two patients had neurofibromatosis Type 2. Lesions were classified as root type (6 tumors), ganglion type (17 tumors), and dumbbell type (10 tumors) based oil their location. The median radiosurgery target Volume was 4.2 cm(3) (range 0.5-18.0 cm(3)), and the median dose to the tumor margin was 15.0 Gy (range 12-20 Gy). Results. At an average of 6 years (range 7.2-147.9 months), the rate of progression-free Survival (PFS) at 1, 5, and 10 years after SRS was 97.0, 82.0, and 82.0%, respectively. Factors associated with improved PFS included female sex, smaller tumor Volume, and a root or ganglion tumor type. Neurological symptoms or signs improved in 11 (33.3%) of 33 patients and were unchanged in 19 (57.6%). Three patients (9.1%) had symptomatic disease progression. Patients who had not undergone a prior tumor resection were significantly more likely to show improvement in neurological symptoms or signs. Conclusions. Stereotactic radiosurgery is ail effective and minimally invasive management option in patients with residual or newly diagnosed trigeminal schwannomas. Predictors of a better treatment response included female sex. smaller tumor Volume, root or ganglion tumor type, and the application of SRS as the primary treatment. (DOI: 10.3171/2008.7.JNS0812)