Clostridia: a flexible microbial platform for the production of alcohols

被引：41

作者：

Ren, Cong ^{[1
,2
]}

Wen, Zhiqiang ^{[3
]}

Xu, Yan ^{[1
,2
]}

Jiang, Weihong ^{[3
,4
]}

Gu, Yang ^{[3
,5
]}

机构：

[1] Jiangnan Univ, State Key Lab Food Sci & Technol, 1800 Lihu Rd, Wuxi 214122, Jiangsu, Peoples R China

[2] Jiangnan Univ, Sch Biotechnol, Key Lab Ind Biotechnol, Minist Educ, 1800 Lihu Rd, Wuxi 214122, Jiangsu, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Synthet Biol, Inst Plant Physiol & Ecol, Shanghai 200032, Peoples R China

[4] SICAM, Jiangsu Natl Synerget Innovat Ctr Adv Mat, 200 North Zhongshan Rd, Nanjing 210009, Jiangsu, Peoples R China

[5] Shanghai Collaborat Innovat Ctr Biomfg Technol, 130 Meilong Rd, Shanghai 200237, Peoples R China

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2016年 / 35卷

基金：

中国国家自然科学基金;

关键词：

ENHANCED BUTANOL PRODUCTION; ACETOBUTYLICUM ATCC 824; ANAEROBIC 1,3-PROPANEDIOL PRODUCTION; SCATOLOGENES STRAIN SL1; N-BUTANOL; SYNGAS FERMENTATION; ACETOGENIC BACTERIA; CO-UTILIZATION; SP-NOV; ETHANOL;

D O I：

10.1016/j.cbpa.2016.08.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Solventogenic clostridia are native producers of ethanol and many higher alcohols employing a broad range of cheap renewable substrates, such as lignocellulosic materials and Cl gases (CO and CO2). These characteristics enable solventogenic clostridia to act as flexible microbial platforms for the production of liquid biofuels. With the rapid development of genetic tools in recent years, the intrinsic intractability of clostridia has been largely overcome, thus, engineering clostridia for production of chemicals and fuels has attracted increasing interests. Here, we provide an overview of recent progress in the production of alcohols based on solventogenic clostridia. Saccharolytic, cellulolytic and gas-fermenting clostridia are discussed, with a special focus on strategies for metabolic engineering to enable and to improve clostridia for the production of higher alcohols.

引用

页码：65 / 72

页数：8

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